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Kynurenine pathway of tryptophan metabolism in pathophysiology and therapy of major depressive disorder

Serotonin deficiency in major depressive disorder (MDD) has formed the basis of antidepressant drug development and was originally attributed to induction of the major tryptophan (Trp)-degrading enzyme, liver Trp 2,3-dioxygenase (TDO), by cortisol, leading to decreased Trp availability to the brain...

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Detalles Bibliográficos
Autores principales:	Badawy, Abdulla A-B, Dawood, Shazia, Bano, Samina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2023
Materias:	Minireviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130957/ https://www.ncbi.nlm.nih.gov/pubmed/37123095 http://dx.doi.org/10.5498/wjp.v13.i4.141

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