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SMARCA4-deficient undifferentiated thoracic tumor: A case report
BACKGROUND: SMARCA4-deficient undifferentiated tumors (SMARCA4-DUTs) present with diverse clinical manifestations and progress to metastasis and even cause death within a few months. This novel subset of undifferentiated tumors occurs in the middle-aged population and is strongly associated with a s...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130994/ https://www.ncbi.nlm.nih.gov/pubmed/37123323 http://dx.doi.org/10.12998/wjcc.v11.i11.2521 |
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author | Kwon, Hee Jung Jang, Min Hye |
author_facet | Kwon, Hee Jung Jang, Min Hye |
author_sort | Kwon, Hee Jung |
collection | PubMed |
description | BACKGROUND: SMARCA4-deficient undifferentiated tumors (SMARCA4-DUTs) present with diverse clinical manifestations and progress to metastasis and even cause death within a few months. This novel subset of undifferentiated tumors occurs in the middle-aged population and is strongly associated with a smoking history. Distinguishing it from other malignancies is challenging. CASE SUMMARY: A 62-year-old man presented with chest pain for 7 d. The patient had no respiratory symptoms and normal pulmonary function test results. The patient had been a smoker for 8 years and quit smoking 2 years ago. Chest computed tomography revealed a huge mass involving the left upper and lower lung lobes with pericardial invasion and multiple metastases. Tumor samples were obtained using open frozen biopsy, after several unsuccessful attempts. The tumor was composed of sheets of undifferentiated disclosive cells with vesicular nuclei and prominent nucleoli. The differential diagnosis included high-grade lymphoma, germ cell tumor, NUT carcinoma, undifferentiated carcinoma, and sarcoma. The tumor cells were large, arranged in sheets, and did not exhibit glandular or squamous differentiation. Frequent foci of necrosis were noted. There was no evidence of epithelial differentiation on immunohistochemical staining. The SMARCA4 stain showed complete loss of expression of SMARCA4, which is diagnostic. CONCLUSION: In the present case, thoracic SMARCA4-DUT was diagnosed based on clinical features, absence of epithelial differentiation, and negative SMARCA4 expression. |
format | Online Article Text |
id | pubmed-10130994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-101309942023-04-27 SMARCA4-deficient undifferentiated thoracic tumor: A case report Kwon, Hee Jung Jang, Min Hye World J Clin Cases Case Report BACKGROUND: SMARCA4-deficient undifferentiated tumors (SMARCA4-DUTs) present with diverse clinical manifestations and progress to metastasis and even cause death within a few months. This novel subset of undifferentiated tumors occurs in the middle-aged population and is strongly associated with a smoking history. Distinguishing it from other malignancies is challenging. CASE SUMMARY: A 62-year-old man presented with chest pain for 7 d. The patient had no respiratory symptoms and normal pulmonary function test results. The patient had been a smoker for 8 years and quit smoking 2 years ago. Chest computed tomography revealed a huge mass involving the left upper and lower lung lobes with pericardial invasion and multiple metastases. Tumor samples were obtained using open frozen biopsy, after several unsuccessful attempts. The tumor was composed of sheets of undifferentiated disclosive cells with vesicular nuclei and prominent nucleoli. The differential diagnosis included high-grade lymphoma, germ cell tumor, NUT carcinoma, undifferentiated carcinoma, and sarcoma. The tumor cells were large, arranged in sheets, and did not exhibit glandular or squamous differentiation. Frequent foci of necrosis were noted. There was no evidence of epithelial differentiation on immunohistochemical staining. The SMARCA4 stain showed complete loss of expression of SMARCA4, which is diagnostic. CONCLUSION: In the present case, thoracic SMARCA4-DUT was diagnosed based on clinical features, absence of epithelial differentiation, and negative SMARCA4 expression. Baishideng Publishing Group Inc 2023-04-16 2023-04-16 /pmc/articles/PMC10130994/ /pubmed/37123323 http://dx.doi.org/10.12998/wjcc.v11.i11.2521 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Report Kwon, Hee Jung Jang, Min Hye SMARCA4-deficient undifferentiated thoracic tumor: A case report |
title |
SMARCA4-deficient undifferentiated thoracic tumor: A case report |
title_full |
SMARCA4-deficient undifferentiated thoracic tumor: A case report |
title_fullStr |
SMARCA4-deficient undifferentiated thoracic tumor: A case report |
title_full_unstemmed |
SMARCA4-deficient undifferentiated thoracic tumor: A case report |
title_short |
SMARCA4-deficient undifferentiated thoracic tumor: A case report |
title_sort | smarca4-deficient undifferentiated thoracic tumor: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130994/ https://www.ncbi.nlm.nih.gov/pubmed/37123323 http://dx.doi.org/10.12998/wjcc.v11.i11.2521 |
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