Difficult-to-treat rheumatoid arthritis treated with Abatacept combined with Baricitinib: A case report

BACKGROUND: Sporadic cases of rheumatoid arthritis (RA) due to unsatisfactory responses to Abatacept (ABT) have been reported; however, the rescue therapy has not been finalized. Here, we present a case with difficult-to-treat RA (D2T RA) that was resistant to either a single ABT or a Janus kinase (...

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Autores principales: Qi, Jia-Ping, Jiang, Huan, Wu, Teng, Zhang, Yuan, Huang, Wei, Li, Yi-Xuan, Wang, Jing, Zhang, Ju, Ying, Zhen-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130995/
https://www.ncbi.nlm.nih.gov/pubmed/37123310
http://dx.doi.org/10.12998/wjcc.v11.i11.2474
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author Qi, Jia-Ping
Jiang, Huan
Wu, Teng
Zhang, Yuan
Huang, Wei
Li, Yi-Xuan
Wang, Jing
Zhang, Ju
Ying, Zhen-Hua
author_facet Qi, Jia-Ping
Jiang, Huan
Wu, Teng
Zhang, Yuan
Huang, Wei
Li, Yi-Xuan
Wang, Jing
Zhang, Ju
Ying, Zhen-Hua
author_sort Qi, Jia-Ping
collection PubMed
description BACKGROUND: Sporadic cases of rheumatoid arthritis (RA) due to unsatisfactory responses to Abatacept (ABT) have been reported; however, the rescue therapy has not been finalized. Here, we present a case with difficult-to-treat RA (D2T RA) that was resistant to either a single ABT or a Janus kinase (JAK) inhibitor (Tofacitinib), but improved with a combination of ABT and JAK inhibitor (Baricitinib, BAT). CASE SUMMARY: A 46-year-old Chinese woman who had RA for ten years that was resistant to Tocilizumab, Etanercept, Adalimumab, and ABT. According to the European League Against Rheumatism definition, the patient was diagnosed with D2T RA. It was then improved with a combination of ABT and a JAK inhibitor BAT. CONCLUSION: ABT combined with BAT may be an acceptable strategy for treating D2T RA.
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spelling pubmed-101309952023-04-27 Difficult-to-treat rheumatoid arthritis treated with Abatacept combined with Baricitinib: A case report Qi, Jia-Ping Jiang, Huan Wu, Teng Zhang, Yuan Huang, Wei Li, Yi-Xuan Wang, Jing Zhang, Ju Ying, Zhen-Hua World J Clin Cases Case Report BACKGROUND: Sporadic cases of rheumatoid arthritis (RA) due to unsatisfactory responses to Abatacept (ABT) have been reported; however, the rescue therapy has not been finalized. Here, we present a case with difficult-to-treat RA (D2T RA) that was resistant to either a single ABT or a Janus kinase (JAK) inhibitor (Tofacitinib), but improved with a combination of ABT and JAK inhibitor (Baricitinib, BAT). CASE SUMMARY: A 46-year-old Chinese woman who had RA for ten years that was resistant to Tocilizumab, Etanercept, Adalimumab, and ABT. According to the European League Against Rheumatism definition, the patient was diagnosed with D2T RA. It was then improved with a combination of ABT and a JAK inhibitor BAT. CONCLUSION: ABT combined with BAT may be an acceptable strategy for treating D2T RA. Baishideng Publishing Group Inc 2023-04-16 2023-04-16 /pmc/articles/PMC10130995/ /pubmed/37123310 http://dx.doi.org/10.12998/wjcc.v11.i11.2474 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Qi, Jia-Ping
Jiang, Huan
Wu, Teng
Zhang, Yuan
Huang, Wei
Li, Yi-Xuan
Wang, Jing
Zhang, Ju
Ying, Zhen-Hua
Difficult-to-treat rheumatoid arthritis treated with Abatacept combined with Baricitinib: A case report
title Difficult-to-treat rheumatoid arthritis treated with Abatacept combined with Baricitinib: A case report
title_full Difficult-to-treat rheumatoid arthritis treated with Abatacept combined with Baricitinib: A case report
title_fullStr Difficult-to-treat rheumatoid arthritis treated with Abatacept combined with Baricitinib: A case report
title_full_unstemmed Difficult-to-treat rheumatoid arthritis treated with Abatacept combined with Baricitinib: A case report
title_short Difficult-to-treat rheumatoid arthritis treated with Abatacept combined with Baricitinib: A case report
title_sort difficult-to-treat rheumatoid arthritis treated with abatacept combined with baricitinib: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130995/
https://www.ncbi.nlm.nih.gov/pubmed/37123310
http://dx.doi.org/10.12998/wjcc.v11.i11.2474
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