Genetic variability of human pegivirus type 1 (HPgV-1) among Congolese co-infected with hepatitis C virus in Brazzaville, Congo

The aim of this study was to determine the rate of human pegivirus type 1 (HPgV-1) and hepatitis C virus (HCV) co-infection, and the genotype distribution of HPgV-1 among patients with chronic hepatitis C and blood donors in Brazzaville. Two groups of patients in Brazzaville were recruited: blood do...

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Detalles Bibliográficos
Autores principales: Niama, Roch Fabien, Mayengue, Pembe Issamou, Nsoukoula, Bertivie Cendres Matongo, Koukouikila-Kossounda, Félix, Badzi, Cynthia Nkoua, Mandiangou, Aldi Fred, Louzolo, Igor, Fila-Fila, Grâce Petula Urielle, Dossou-Yovo, Louis Régis, Angounda, Monic Brunel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131043/
https://www.ncbi.nlm.nih.gov/pubmed/37123381
http://dx.doi.org/10.1016/j.ijregi.2023.03.005
Descripción
Sumario:The aim of this study was to determine the rate of human pegivirus type 1 (HPgV-1) and hepatitis C virus (HCV) co-infection, and the genotype distribution of HPgV-1 among patients with chronic hepatitis C and blood donors in Brazzaville. Two groups of patients in Brazzaville were recruited: blood donors (n = 35) and individuals with chronic hepatitis C (n = 73). The overall positivity rate of HPgV-1 was 4.63%: 2.86% in blood donors and 5.48% in chronic hepatitis C patients. Phylogenetic analysis showed that all samples were genotype 1. However, studies with a larger sample size are needed to estimate the true burden of HPgV-1 infection in the country and to confirm the distribution of genotypes in the general population.

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