HiPSC-derived cardiomyocyte to model Brugada syndrome: both asymptomatic and symptomatic mutation carriers reveal increased arrhythmogenicity

Brugada syndrome is an inherited cardiac arrhythmia disorder that is mainly associated with mutations of the cardiac voltage-gated sodium channel alpha subunit 5 (SCN5A) gene. The clinical symptoms include ventricular fibrillation and an increased risk of sudden cardiac death. Human-induced pluripot...

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Detalles Bibliográficos
Autores principales: Penttinen, Kirsi, Prajapati, Chandra, Shah, Disheet, Rajan, Dhanesh Kattipparambil, Cherian, Reeja Maria, Swan, Heikki, Aalto-Setälä, Katriina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131315/
https://www.ncbi.nlm.nih.gov/pubmed/37098502
http://dx.doi.org/10.1186/s12872-023-03234-7

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