A comprehensive map of human glucokinase variant activity

BACKGROUND: Glucokinase (GCK) regulates insulin secretion to maintain appropriate blood glucose levels. Sequence variants can alter GCK activity to cause hyperinsulinemic hypoglycemia or hyperglycemia associated with GCK-maturity-onset diabetes of the young (GCK-MODY), collectively affecting up to 1...

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Detalles Bibliográficos
Autores principales: Gersing, Sarah, Cagiada, Matteo, Gebbia, Marinella, Gjesing, Anette P., Coté, Atina G., Seesankar, Gireesh, Li, Roujia, Tabet, Daniel, Weile, Jochen, Stein, Amelie, Gloyn, Anna L., Hansen, Torben, Roth, Frederick P., Lindorff-Larsen, Kresten, Hartmann-Petersen, Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131484/
https://www.ncbi.nlm.nih.gov/pubmed/37101203
http://dx.doi.org/10.1186/s13059-023-02935-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131484/
https://www.ncbi.nlm.nih.gov/pubmed/37101203
http://dx.doi.org/10.1186/s13059-023-02935-8

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