Cargando…

Dynamic ctDNA Mutational Complexity in Patients with Melanoma Receiving Immunotherapy

BACKGROUND: Circulating tumour DNA (ctDNA) analysis promises to improve the clinical care of people with cancer, address health inequities and guide translational research. This observational cohort study used ctDNA to follow 29 patients with advanced-stage cutaneous melanoma through multiple cycles...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fitzgerald, Sandra, Blenkiron, Cherie, Stephens, Rosalie, Mathy, Jon A., Somers-Edgar, Tiffany, Rolfe, Gill, Martin, Richard, Jackson, Christopher, Eccles, Michael, Robb, Tamsin, Rodger, Euan, Lawrence, Ben, Guilford, Parry, Lasham, Annette, Print, Cristin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131510/ https://www.ncbi.nlm.nih.gov/pubmed/37099071 http://dx.doi.org/10.1007/s40291-023-00651-4

Ejemplares similares

Links between the Oncoprotein YB-1 and Small Non-Coding RNAs in Breast Cancer
por: Blenkiron, Cherie, et al.
Publicado: (2013)

Complex Patterns of Genomic Heterogeneity Identified in 42 Tumor Samples and ctDNA of a Pulmonary Atypical Carcinoid Patient
por: Robb, Tamsin J., et al.
Publicado: (2023)

Reviving the Autopsy for Modern Cancer Evolution Research
por: Robb, Tamsin Joy, et al.
Publicado: (2021)

Accessing a New Dimension in TP53 Biology: Multiplex Long Amplicon Digital PCR to Specifically Detect and Quantitate Individual TP53 Transcripts
por: Lasham, Annette, et al.
Publicado: (2020)

Breast Cancer Patient Prognosis Is Determined by the Interplay between TP53 Mutation and Alternative Transcript Expression: Insights from TP53 Long Amplicon Digital PCR Assays
por: Lasham, Annette, et al.
Publicado: (2021)

Uropathogenic Escherichia coli Releases Extracellular Vesicles That Are Associated with RNA
por: Blenkiron, Cherie, et al.
Publicado: (2016)

Extensive Inter-Cyst DNA Methylation Variation in Autosomal Dominant Polycystic Kidney Disease Revealed by Genome Scale Sequencing
por: Bowden, Sarah A., et al.
Publicado: (2020)

Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease
por: Bowden, Sarah A., et al.
Publicado: (2021)

Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1
por: Trevarton, AlexanderJ., et al.
Publicado: (2019)

Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes
por: Mehta, Sunali Y., et al.
Publicado: (2018)

Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma
por: Tran, Khanh B., et al.
Publicado: (2020)

The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation
por: Kang, Matthew, et al.
Publicado: (2023)

Role of ctDNA in Breast Cancer
por: Sant, Marta, et al.
Publicado: (2022)

The Role of ctDNA in Gastric Cancer
por: Mencel, Justin, et al.
Publicado: (2022)

Utility of ctDNA Liquid Biopsies from Cancer Patients: An Institutional Study of 285 ctDNA Samples
por: Gumà, Josep, et al.
Publicado: (2022)

Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context
por: Paterson, Emily, et al.
Publicado: (2022)

Diverse Developmental Disorders from The One Ring: Distinct Molecular Pathways Underlie the Cohesinopathies
por: Horsfield, Julia A., et al.
Publicado: (2012)

GeneSetDB: A comprehensive meta-database, statistical and visualisation framework for gene set analysis
por: Araki, Hiromitsu, et al.
Publicado: (2012)

Close Links between Cold Shock Proteins and Cancer
por: Toulany, Mahmoud, et al.
Publicado: (2023)

Transcriptional Reprogramming and Constitutive PD-L1 Expression in Melanoma Are Associated with Dedifferentiation and Activation of Interferon and Tumour Necrosis Factor Signalling Pathways
por: Ahn, Antonio, et al.
Publicado: (2021)

Bacterial RNA as a signal to eukaryotic cells as part of the infection process
por: Simonov, Denis, et al.
Publicado: (2016)

Biodistribution of extracellular vesicles following administration into animals: A systematic review
por: Kang, Matthew, et al.
Publicado: (2021)

Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types
por: Rodger, Euan J., et al.
Publicado: (2019)

Biclustering reveals breast cancer tumour subgroups with common clinical features and improves prediction of disease recurrence
por: Wang, Yi Kan, et al.
Publicado: (2013)

Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer
por: Lawrence, Ben, et al.
Publicado: (2018)

Emerging Roles of miRNAs in Brain Development and Perinatal Brain Injury
por: Cho, Kenta Hyeon Tae, et al.
Publicado: (2019)

Liquid Biopsy, ctDNA Diagnosis through NGS
por: Lin, Chen, et al.
Publicado: (2021)

ctDNA as a biomarker of progression in oesophageal adenocarcinoma
por: Bonazzi, V.F., et al.
Publicado: (2022)

State of the Art: ctDNA in Upper Gastrointestinal Malignancies
por: Labiano, Ibone, et al.
Publicado: (2023)

A Zebrafish Model of Roberts Syndrome Reveals That Esco2 Depletion Interferes with Development by Disrupting the Cell Cycle
por: Mönnich, Maren, et al.
Publicado: (2011)

The Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours
por: Rosario, Roseanne, et al.
Publicado: (2012)

Inflammatory Cytokines and ctDNA Are Biomarkers for Progression in Advanced-Stage Melanoma Patients Receiving Checkpoint Inhibitors
por: Pedersen, Jesper Geert, et al.
Publicado: (2020)

Effect of the Extracellular Vesicle RNA Cargo From Uropathogenic Escherichia coli on Bladder Cells
por: Dauros-Singorenko, Priscila, et al.
Publicado: (2020)

Protocol for generating high-quality genome-scale DNA methylation sequencing data from human cancer biospecimens
por: Rodger, Euan J., et al.
Publicado: (2023)

The circulating tumor DNA (ctDNA) alteration level predicts therapeutic response in metastatic breast cancer: Novel prognostic indexes based on ctDNA
por: Liu, Binliang, et al.
Publicado: (2022)

Potential value of ctDNA monitoring in metastatic HR + /HER2 − breast cancer: longitudinal ctDNA analysis in the phase Ib MONALEESASIA trial
por: Chiu, Joanne, et al.
Publicado: (2023)

Detection of ctDNA in the plasma of patients with papillary thyroid carcinoma
por: Li, Huiqiang, et al.
Publicado: (2019)

ctDNA: An emerging neoadjuvant biomarker in resectable solid tumors
por: Abbosh, Christopher, et al.
Publicado: (2021)

Current status of ctDNA in precision oncology for hepatocellular carcinoma
por: Li, Yan, et al.
Publicado: (2021)

The potential, analysis and prospect of ctDNA sequencing in hepatocellular carcinoma
por: Ding, Yubo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_53jvg3vgt1s65f7njvs57ub7g2