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Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors (Adv. Sci. 12/2023)
Cancer Immunotherapy In article number 2205044, Baorui Liu, Rutian Li, and co‐workers constructed gelatinase‐responsive NanoSwitch to control the activation process of CAR‐T cells, leading to on‐site activation of CAR‐T cells at the tumor region in a sustainable way. This platform has promising pote...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131794/ http://dx.doi.org/10.1002/advs.202370074 |
| _version_ | 1785031254683418624 |
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| author | Wang, Xinyue Meng, Fanyan Li, Xiang Xue, Luxin Chen, Anni Qiu, Yuling Zhang, Zhifan Li, Lin Liu, Fengcen Li, Yishan Sun, Zhichen Chu, Yanhong Xu, Ruihan Yu, Lixia Shao, Jie Tian, Manman Qian, Xiaoping Liu, Qin Liu, Baorui Li, Rutian |
| author_facet | Wang, Xinyue Meng, Fanyan Li, Xiang Xue, Luxin Chen, Anni Qiu, Yuling Zhang, Zhifan Li, Lin Liu, Fengcen Li, Yishan Sun, Zhichen Chu, Yanhong Xu, Ruihan Yu, Lixia Shao, Jie Tian, Manman Qian, Xiaoping Liu, Qin Liu, Baorui Li, Rutian |
| author_sort | Wang, Xinyue |
| collection | PubMed |
| description | Cancer Immunotherapy In article number 2205044, Baorui Liu, Rutian Li, and co‐workers constructed gelatinase‐responsive NanoSwitch to control the activation process of CAR‐T cells, leading to on‐site activation of CAR‐T cells at the tumor region in a sustainable way. This platform has promising potential to prevent the main obstacles in the CAR‐T therapy for solid tumors including cytokine‐release syndrome and on‐target/off‐tumor toxicity. [Image: see text] |
| format | Online Article Text |
| id | pubmed-10131794 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-101317942023-04-27 Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors (Adv. Sci. 12/2023) Wang, Xinyue Meng, Fanyan Li, Xiang Xue, Luxin Chen, Anni Qiu, Yuling Zhang, Zhifan Li, Lin Liu, Fengcen Li, Yishan Sun, Zhichen Chu, Yanhong Xu, Ruihan Yu, Lixia Shao, Jie Tian, Manman Qian, Xiaoping Liu, Qin Liu, Baorui Li, Rutian Adv Sci (Weinh) Back Cover Cancer Immunotherapy In article number 2205044, Baorui Liu, Rutian Li, and co‐workers constructed gelatinase‐responsive NanoSwitch to control the activation process of CAR‐T cells, leading to on‐site activation of CAR‐T cells at the tumor region in a sustainable way. This platform has promising potential to prevent the main obstacles in the CAR‐T therapy for solid tumors including cytokine‐release syndrome and on‐target/off‐tumor toxicity. [Image: see text] John Wiley and Sons Inc. 2023-04-26 /pmc/articles/PMC10131794/ http://dx.doi.org/10.1002/advs.202370074 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Back Cover Wang, Xinyue Meng, Fanyan Li, Xiang Xue, Luxin Chen, Anni Qiu, Yuling Zhang, Zhifan Li, Lin Liu, Fengcen Li, Yishan Sun, Zhichen Chu, Yanhong Xu, Ruihan Yu, Lixia Shao, Jie Tian, Manman Qian, Xiaoping Liu, Qin Liu, Baorui Li, Rutian Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors (Adv. Sci. 12/2023) |
| title | Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors (Adv. Sci. 12/2023) |
| title_full | Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors (Adv. Sci. 12/2023) |
| title_fullStr | Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors (Adv. Sci. 12/2023) |
| title_full_unstemmed | Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors (Adv. Sci. 12/2023) |
| title_short | Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors (Adv. Sci. 12/2023) |
| title_sort | nanomodified switch induced precise and moderate activation of car‐t cells for solid tumors (adv. sci. 12/2023) |
| topic | Back Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131794/ http://dx.doi.org/10.1002/advs.202370074 |
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