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Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants

The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on...

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Detalles Bibliográficos
Autores principales: Talebian, Sepehr, Mendes, Bárbara, Conniot, João, Farajikhah, Syamak, Dehghani, Fariba, Li, Zhongyan, Bitoque, Diogo, Silva, Gabriela, Naficy, Sina, Conde, João, Wallace, Gordon G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131825/
https://www.ncbi.nlm.nih.gov/pubmed/36782094
http://dx.doi.org/10.1002/advs.202207603
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author Talebian, Sepehr
Mendes, Bárbara
Conniot, João
Farajikhah, Syamak
Dehghani, Fariba
Li, Zhongyan
Bitoque, Diogo
Silva, Gabriela
Naficy, Sina
Conde, João
Wallace, Gordon G.
author_facet Talebian, Sepehr
Mendes, Bárbara
Conniot, João
Farajikhah, Syamak
Dehghani, Fariba
Li, Zhongyan
Bitoque, Diogo
Silva, Gabriela
Naficy, Sina
Conde, João
Wallace, Gordon G.
author_sort Talebian, Sepehr
collection PubMed
description The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug‐loaded biopolymeric coatings for biomedical implants are highlighted.
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spelling pubmed-101318252023-04-27 Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants Talebian, Sepehr Mendes, Bárbara Conniot, João Farajikhah, Syamak Dehghani, Fariba Li, Zhongyan Bitoque, Diogo Silva, Gabriela Naficy, Sina Conde, João Wallace, Gordon G. Adv Sci (Weinh) Reviews The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug‐loaded biopolymeric coatings for biomedical implants are highlighted. John Wiley and Sons Inc. 2023-02-13 /pmc/articles/PMC10131825/ /pubmed/36782094 http://dx.doi.org/10.1002/advs.202207603 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Talebian, Sepehr
Mendes, Bárbara
Conniot, João
Farajikhah, Syamak
Dehghani, Fariba
Li, Zhongyan
Bitoque, Diogo
Silva, Gabriela
Naficy, Sina
Conde, João
Wallace, Gordon G.
Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants
title Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants
title_full Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants
title_fullStr Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants
title_full_unstemmed Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants
title_short Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants
title_sort biopolymeric coatings for local release of therapeutics from biomedical implants
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131825/
https://www.ncbi.nlm.nih.gov/pubmed/36782094
http://dx.doi.org/10.1002/advs.202207603
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