Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines

An enantioselective hydrophosphination of alkenyl isoquinolines is developed by using a copper-chiral diphosphine ligand catalyst. It provides a direct and atom-efficient approach to prepare a variety of chiral phosphines with an isoquinoline unit in good yields and high enantioselectivities. In add...

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Detalles Bibliográficos
Autores principales: Yang, Qingjing, Zhou, Jian, Wang, Jun (Joelle)
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132128/
https://www.ncbi.nlm.nih.gov/pubmed/37123192
http://dx.doi.org/10.1039/d2sc06950d
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author Yang, Qingjing
Zhou, Jian
Wang, Jun (Joelle)
author_facet Yang, Qingjing
Zhou, Jian
Wang, Jun (Joelle)
author_sort Yang, Qingjing
collection PubMed
description An enantioselective hydrophosphination of alkenyl isoquinolines is developed by using a copper-chiral diphosphine ligand catalyst. It provides a direct and atom-efficient approach to prepare a variety of chiral phosphines with an isoquinoline unit in good yields and high enantioselectivities. In addition, these chiral phosphine products are useful bidentate P,N-ligands which showed potential application in asymmetric catalysis.
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spelling pubmed-101321282023-04-27 Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines Yang, Qingjing Zhou, Jian Wang, Jun (Joelle) Chem Sci Chemistry An enantioselective hydrophosphination of alkenyl isoquinolines is developed by using a copper-chiral diphosphine ligand catalyst. It provides a direct and atom-efficient approach to prepare a variety of chiral phosphines with an isoquinoline unit in good yields and high enantioselectivities. In addition, these chiral phosphine products are useful bidentate P,N-ligands which showed potential application in asymmetric catalysis. The Royal Society of Chemistry 2023-03-21 /pmc/articles/PMC10132128/ /pubmed/37123192 http://dx.doi.org/10.1039/d2sc06950d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yang, Qingjing
Zhou, Jian
Wang, Jun (Joelle)
Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines
title Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines
title_full Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines
title_fullStr Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines
title_full_unstemmed Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines
title_short Enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines
title_sort enantioselective copper-catalyzed hydrophosphination of alkenyl isoquinolines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132128/
https://www.ncbi.nlm.nih.gov/pubmed/37123192
http://dx.doi.org/10.1039/d2sc06950d
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AT zhoujian enantioselectivecoppercatalyzedhydrophosphinationofalkenylisoquinolines
AT wangjunjoelle enantioselectivecoppercatalyzedhydrophosphinationofalkenylisoquinolines

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