25-Hydroxycholesterol exacerbates vascular leak during acute lung injury

Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined. Recently, we reported that Ch25h is induced in monocyte-derived macrophages recruited to the airspace during resolution...

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Detalles Bibliográficos
Autores principales: Madenspacher, Jennifer H., Morrell, Eric D., McDonald, Jeffrey G., Thompson, Bonne M., Li, Yue, Birukov, Konstantin G., Birukova, Anna A., Stapleton, Renee D., Alejo, Aidin, Karmaus, Peer W., Meacham, Julie M., Rai, Prashant, Mikacenic, Carmen, Wurfel, Mark M., Fessler, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132150/
https://www.ncbi.nlm.nih.gov/pubmed/36821369
http://dx.doi.org/10.1172/jci.insight.155448

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