The mRNA-binding protein DDX3 mediates TGF-β1 upregulation of translation and promotes pulmonary fibrosis

Pulmonary fibrosis is potentiated by a positive feedback loop involving the extracellular sialidase enzyme neuraminidase 3 (NEU3) causing release of active TGF-β1 and TGF-β1 upregulating NEU3 by increasing translation without affecting mRNA levels. In this report, we elucidate the TGF-β1 upregulatio...

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Detalles Bibliográficos
Autores principales: Chen, Wensheng, Pilling, Darrell, Gomer, Richard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132153/
https://www.ncbi.nlm.nih.gov/pubmed/36821384
http://dx.doi.org/10.1172/jci.insight.167566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132153/
https://www.ncbi.nlm.nih.gov/pubmed/36821384
http://dx.doi.org/10.1172/jci.insight.167566

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