LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

Cerebrovasculature is critical in maintaining brain homeostasis; its dysregulation often leads to vascular cognitive impairment and dementia (VCID) during aging. VCID is the second most prevalent cause of dementia in the elderly, after Alzheimer’s disease (AD), with frequent cooccurrence of VCID and...

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Detalles Bibliográficos
Autores principales: Oue, Hiroshi, Yamazaki, Yu, Qiao, Wenhui, Yuanxin, Chen, Ren, Yingxue, Kurti, Aishe, Shue, Francis, Parsons, Tammee M., Perkerson, Ralph B., Kawatani, Keiji, Wang, Ni, Starling, Skylar C., Roy, Bhaskar, Mosneag, Ioana-Emilia, Aikawa, Tomonori, Holm, Marie-Louise, Liu, Chia-Chen, Inoue, Yasuteru, Sullivan, Patrick M., Asmann, Yan W., Kim, Betty Y.S., Bu, Guojun, Kanekiyo, Takahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132158/
https://www.ncbi.nlm.nih.gov/pubmed/37036005
http://dx.doi.org/10.1172/jci.insight.163822

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