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Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations
Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform la...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132160/ https://www.ncbi.nlm.nih.gov/pubmed/37036009 http://dx.doi.org/10.1172/jci.insight.165867 |
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author | Robbins, Jeremy M. Rao, Prashant Deng, Shuliang Keyes, Michelle J. Tahir, Usman A. Katz, Daniel H. Beltran, Pierre M. Jean Marchildon, François Barber, Jacob L. Peterson, Bennet Gao, Yan Correa, Adolfo Wilson, James G. Smith, J. Gustav Cohen, Paul Ross, Robert Bouchard, Claude Sarzynski, Mark A. Gerszten, Robert E. |
author_facet | Robbins, Jeremy M. Rao, Prashant Deng, Shuliang Keyes, Michelle J. Tahir, Usman A. Katz, Daniel H. Beltran, Pierre M. Jean Marchildon, François Barber, Jacob L. Peterson, Bennet Gao, Yan Correa, Adolfo Wilson, James G. Smith, J. Gustav Cohen, Paul Ross, Robert Bouchard, Claude Sarzynski, Mark A. Gerszten, Robert E. |
author_sort | Robbins, Jeremy M. |
collection | PubMed |
description | Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supervised, 20-week endurance exercise training intervention. We identify hundreds of circulating proteins that are modulated, many of which are known to be secreted. We highlight proteins involved in angiogenesis, iron homeostasis, and the extracellular matrix, many of which are novel, including training-induced increases in fibroblast activation protein (FAP), a membrane-bound and circulating protein relevant in body-composition homeostasis. We relate protein changes to training-induced maximal oxygen uptake adaptations and validate our top findings in an external exercise cohort. Furthermore, we show that FAP is positively associated with survival in 3 separate, population-based cohorts. |
format | Online Article Text |
id | pubmed-10132160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Society for Clinical Investigation |
record_format | MEDLINE/PubMed |
spelling | pubmed-101321602023-04-27 Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations Robbins, Jeremy M. Rao, Prashant Deng, Shuliang Keyes, Michelle J. Tahir, Usman A. Katz, Daniel H. Beltran, Pierre M. Jean Marchildon, François Barber, Jacob L. Peterson, Bennet Gao, Yan Correa, Adolfo Wilson, James G. Smith, J. Gustav Cohen, Paul Ross, Robert Bouchard, Claude Sarzynski, Mark A. Gerszten, Robert E. JCI Insight Technical Advance Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supervised, 20-week endurance exercise training intervention. We identify hundreds of circulating proteins that are modulated, many of which are known to be secreted. We highlight proteins involved in angiogenesis, iron homeostasis, and the extracellular matrix, many of which are novel, including training-induced increases in fibroblast activation protein (FAP), a membrane-bound and circulating protein relevant in body-composition homeostasis. We relate protein changes to training-induced maximal oxygen uptake adaptations and validate our top findings in an external exercise cohort. Furthermore, we show that FAP is positively associated with survival in 3 separate, population-based cohorts. American Society for Clinical Investigation 2023-04-10 /pmc/articles/PMC10132160/ /pubmed/37036009 http://dx.doi.org/10.1172/jci.insight.165867 Text en © 2023 Robbins et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Technical Advance Robbins, Jeremy M. Rao, Prashant Deng, Shuliang Keyes, Michelle J. Tahir, Usman A. Katz, Daniel H. Beltran, Pierre M. Jean Marchildon, François Barber, Jacob L. Peterson, Bennet Gao, Yan Correa, Adolfo Wilson, James G. Smith, J. Gustav Cohen, Paul Ross, Robert Bouchard, Claude Sarzynski, Mark A. Gerszten, Robert E. Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations |
title | Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations |
title_full | Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations |
title_fullStr | Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations |
title_full_unstemmed | Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations |
title_short | Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations |
title_sort | plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations |
topic | Technical Advance |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132160/ https://www.ncbi.nlm.nih.gov/pubmed/37036009 http://dx.doi.org/10.1172/jci.insight.165867 |
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