NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions

Low capacity to produce ROS because of mutations in neutrophil cytosolic factor 1 (NCF1/p47phox), a component of NADPH oxidase 2 (NOX2) complex, is strongly associated with systemic lupus erythematosus in both humans and mouse models. Here, we aimed to identify the key immune cell type(s) and cellul...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Huqiao, Urbonaviciute, Vilma, Saei, Amir Ata, Lyu, Hezheng, Gaetani, Massimiliano, Végvári, Ákos, Li, Yanpeng, Zubarev, Roman A., Holmdahl, Rikard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132169/
https://www.ncbi.nlm.nih.gov/pubmed/36853827
http://dx.doi.org/10.1172/jci.insight.164875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132169/
https://www.ncbi.nlm.nih.gov/pubmed/36853827
http://dx.doi.org/10.1172/jci.insight.164875

Ejemplares similares