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NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions

Low capacity to produce ROS because of mutations in neutrophil cytosolic factor 1 (NCF1/p47phox), a component of NADPH oxidase 2 (NOX2) complex, is strongly associated with systemic lupus erythematosus in both humans and mouse models. Here, we aimed to identify the key immune cell type(s) and cellul...

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Detalles Bibliográficos
Autores principales:	Luo, Huqiao, Urbonaviciute, Vilma, Saei, Amir Ata, Lyu, Hezheng, Gaetani, Massimiliano, Végvári, Ákos, Li, Yanpeng, Zubarev, Roman A., Holmdahl, Rikard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132169/ https://www.ncbi.nlm.nih.gov/pubmed/36853827 http://dx.doi.org/10.1172/jci.insight.164875

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