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Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor‐positive breast cancer: a systematic review and meta-analysis
CONTEXT: Chinese medicinal herbs (CMH) have been considered a potentially efficacious approach for patients with breast cancer that experience adverse effects from endocrine treatment. OBJECTIVE: To investigate the impact of CMH on endocrine therapy-induced side effects in patients with hormone rece...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132232/ https://www.ncbi.nlm.nih.gov/pubmed/37096936 http://dx.doi.org/10.1080/13880209.2023.2203193 |
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author | Chen, Shaoqing Gao, Yifang Liu, Haichao Jing, Jin Yang, Zhengyu Zhu, Haoming Chen, Bairui Wang, Yu Zhang, Ting Wang, Shizhong Lin, Jianping |
author_facet | Chen, Shaoqing Gao, Yifang Liu, Haichao Jing, Jin Yang, Zhengyu Zhu, Haoming Chen, Bairui Wang, Yu Zhang, Ting Wang, Shizhong Lin, Jianping |
author_sort | Chen, Shaoqing |
collection | PubMed |
description | CONTEXT: Chinese medicinal herbs (CMH) have been considered a potentially efficacious approach for patients with breast cancer that experience adverse effects from endocrine treatment. OBJECTIVE: To investigate the impact of CMH on endocrine therapy-induced side effects in patients with hormone receptor-positive (HR+) breast cancer. METHODS: Ten databases (e.g., PubMed, Web of Science, Cochrane Library, China National Knowledge Information Database and other databases) were searched up to 20 May 2022. The search terms included Chinese herb, breast cancer, endocrine therapy, clinical trial and their mesh terms. The study selection and data extraction were performed by two independent reviewers. The risk of bias was evaluated using the Cochrane risk of bias method. RESULTS: A total of 31 studies with 2288 patients were included. There were significant improvements in bone mineral density (BMD) [lumbar BMD (MD 0.08, 95% CI 0.07 to 0.09, p < 0.00001) and femoral neck BMD (MD 0.08, 95% CI 0.07 to 0.10, p < 0.00001)] and bone gal protein (BGP) (MD 0.24, 95% CI 0.17 to 0.31, p < 0.00001), with a significant reduction in triglycerides (MD −0.53, 95% CI −1.00 to −0.07, p < 0.05) and no effect on estradiol levels (MD 0.90, 95% CI −0.31 to 2.12, p = 0.15). CONCLUSIONS: CMH combined with complementary therapy can moderately reduce endocrine therapy-induced side effects, including bone loss and dyslipidemia in patients with HR + breast cancer, revealing the potential role of CMH in treating (HR+) breast cancer. More high-quality RCTs are warranted to further validate the effectiveness and safety of CMH. |
format | Online Article Text |
id | pubmed-10132232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-101322322023-04-27 Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor‐positive breast cancer: a systematic review and meta-analysis Chen, Shaoqing Gao, Yifang Liu, Haichao Jing, Jin Yang, Zhengyu Zhu, Haoming Chen, Bairui Wang, Yu Zhang, Ting Wang, Shizhong Lin, Jianping Pharm Biol Research Article CONTEXT: Chinese medicinal herbs (CMH) have been considered a potentially efficacious approach for patients with breast cancer that experience adverse effects from endocrine treatment. OBJECTIVE: To investigate the impact of CMH on endocrine therapy-induced side effects in patients with hormone receptor-positive (HR+) breast cancer. METHODS: Ten databases (e.g., PubMed, Web of Science, Cochrane Library, China National Knowledge Information Database and other databases) were searched up to 20 May 2022. The search terms included Chinese herb, breast cancer, endocrine therapy, clinical trial and their mesh terms. The study selection and data extraction were performed by two independent reviewers. The risk of bias was evaluated using the Cochrane risk of bias method. RESULTS: A total of 31 studies with 2288 patients were included. There were significant improvements in bone mineral density (BMD) [lumbar BMD (MD 0.08, 95% CI 0.07 to 0.09, p < 0.00001) and femoral neck BMD (MD 0.08, 95% CI 0.07 to 0.10, p < 0.00001)] and bone gal protein (BGP) (MD 0.24, 95% CI 0.17 to 0.31, p < 0.00001), with a significant reduction in triglycerides (MD −0.53, 95% CI −1.00 to −0.07, p < 0.05) and no effect on estradiol levels (MD 0.90, 95% CI −0.31 to 2.12, p = 0.15). CONCLUSIONS: CMH combined with complementary therapy can moderately reduce endocrine therapy-induced side effects, including bone loss and dyslipidemia in patients with HR + breast cancer, revealing the potential role of CMH in treating (HR+) breast cancer. More high-quality RCTs are warranted to further validate the effectiveness and safety of CMH. Taylor & Francis 2023-04-25 /pmc/articles/PMC10132232/ /pubmed/37096936 http://dx.doi.org/10.1080/13880209.2023.2203193 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Research Article Chen, Shaoqing Gao, Yifang Liu, Haichao Jing, Jin Yang, Zhengyu Zhu, Haoming Chen, Bairui Wang, Yu Zhang, Ting Wang, Shizhong Lin, Jianping Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor‐positive breast cancer: a systematic review and meta-analysis |
title | Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor‐positive breast cancer: a systematic review and meta-analysis |
title_full | Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor‐positive breast cancer: a systematic review and meta-analysis |
title_fullStr | Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor‐positive breast cancer: a systematic review and meta-analysis |
title_full_unstemmed | Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor‐positive breast cancer: a systematic review and meta-analysis |
title_short | Chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor‐positive breast cancer: a systematic review and meta-analysis |
title_sort | chinese medicinal herbs for reducing endocrine therapy-induced side effects in patients with hormone receptor‐positive breast cancer: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132232/ https://www.ncbi.nlm.nih.gov/pubmed/37096936 http://dx.doi.org/10.1080/13880209.2023.2203193 |
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