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Pattern of drug resistant Mycobacterium tuberculosis in the west and northwest of Iran: a meta-analysis

BACKGROUND AND OBJECTIVES: Drug-resistant tuberculosis (Tb) is a major public health issue across the world. Therefore, it is crucial to determine its pattern in different regions of the world. The aim of this study was to review the prevalence of drug resistant TB in the west and northwest of Iran....

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Autores principales: Ansarin, Khalil, Sahebi, Leyla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132330/
https://www.ncbi.nlm.nih.gov/pubmed/37124845
http://dx.doi.org/10.18502/ijm.v14i3.9754
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author Ansarin, Khalil
Sahebi, Leyla
author_facet Ansarin, Khalil
Sahebi, Leyla
author_sort Ansarin, Khalil
collection PubMed
description BACKGROUND AND OBJECTIVES: Drug-resistant tuberculosis (Tb) is a major public health issue across the world. Therefore, it is crucial to determine its pattern in different regions of the world. The aim of this study was to review the prevalence of drug resistant TB in the west and northwest of Iran. MATERIALS AND METHODS: A systematic literature search was performed to identify studies (2010 to 2021) in Google Scholar, PubMed, Thomson Reuters, Scientific Information Database (SID), Cochrane Library, and Medical Library (MedLib) databases. The patterns of any drug-resistant Mycobacterium tuberculosis (MTB); resistance to isoniazid (INH), rifampicin (RMP), streptomycin (SMP), ethambutol (EMB), and multiple drug resistance (MDR) were reviewed in tuberculosis in the west and northwest of Iran. RESULTS: In this review, 7 studies met the eligibility criteria for a meta-analysis. The pooled proportion of any drug resistant TB was 13% (CI 95%: 9.0, 17.0) (43.0% in re-treatment group). The pooled prevalence of any drug resistant TB was more than 1.5 times higher in men compared to women (15% vs. 9.0%). The pooled prevalence (%) of resistance to INH, RMP, SMP, EMB and MDR-TB was 11.0%, 12.0%, 13.0%, 6.0%, and 6.0%, respectively. Kermanshah Province (a province in the west of Iran) showed a high prevalence of any type of drug resistance and MDR-TB (15.9% and 20.0%, respectively). CONCLUSION: It seems that the western provinces of Iran have a different pattern of drug resistance compared to the northwestern provinces. Considering the extent of Iran and the neighboring countries, it is recommended that the pattern of tuberculosis drug resistance be reviewed separately in different provinces or regions of Iran. Drug resistance in the re-treatment group was more than three times that of all patients with TB drug resistance. The burden of drug resistance reduces significantly with better control and management of TB drug treatment and preventing re-infection.
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spelling pubmed-101323302023-04-27 Pattern of drug resistant Mycobacterium tuberculosis in the west and northwest of Iran: a meta-analysis Ansarin, Khalil Sahebi, Leyla Iran J Microbiol Meta-Analysis Article BACKGROUND AND OBJECTIVES: Drug-resistant tuberculosis (Tb) is a major public health issue across the world. Therefore, it is crucial to determine its pattern in different regions of the world. The aim of this study was to review the prevalence of drug resistant TB in the west and northwest of Iran. MATERIALS AND METHODS: A systematic literature search was performed to identify studies (2010 to 2021) in Google Scholar, PubMed, Thomson Reuters, Scientific Information Database (SID), Cochrane Library, and Medical Library (MedLib) databases. The patterns of any drug-resistant Mycobacterium tuberculosis (MTB); resistance to isoniazid (INH), rifampicin (RMP), streptomycin (SMP), ethambutol (EMB), and multiple drug resistance (MDR) were reviewed in tuberculosis in the west and northwest of Iran. RESULTS: In this review, 7 studies met the eligibility criteria for a meta-analysis. The pooled proportion of any drug resistant TB was 13% (CI 95%: 9.0, 17.0) (43.0% in re-treatment group). The pooled prevalence of any drug resistant TB was more than 1.5 times higher in men compared to women (15% vs. 9.0%). The pooled prevalence (%) of resistance to INH, RMP, SMP, EMB and MDR-TB was 11.0%, 12.0%, 13.0%, 6.0%, and 6.0%, respectively. Kermanshah Province (a province in the west of Iran) showed a high prevalence of any type of drug resistance and MDR-TB (15.9% and 20.0%, respectively). CONCLUSION: It seems that the western provinces of Iran have a different pattern of drug resistance compared to the northwestern provinces. Considering the extent of Iran and the neighboring countries, it is recommended that the pattern of tuberculosis drug resistance be reviewed separately in different provinces or regions of Iran. Drug resistance in the re-treatment group was more than three times that of all patients with TB drug resistance. The burden of drug resistance reduces significantly with better control and management of TB drug treatment and preventing re-infection. Tehran University of Medical Sciences 2022-06 /pmc/articles/PMC10132330/ /pubmed/37124845 http://dx.doi.org/10.18502/ijm.v14i3.9754 Text en Copyright © 2022 The Authors. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Meta-Analysis Article
Ansarin, Khalil
Sahebi, Leyla
Pattern of drug resistant Mycobacterium tuberculosis in the west and northwest of Iran: a meta-analysis
title Pattern of drug resistant Mycobacterium tuberculosis in the west and northwest of Iran: a meta-analysis
title_full Pattern of drug resistant Mycobacterium tuberculosis in the west and northwest of Iran: a meta-analysis
title_fullStr Pattern of drug resistant Mycobacterium tuberculosis in the west and northwest of Iran: a meta-analysis
title_full_unstemmed Pattern of drug resistant Mycobacterium tuberculosis in the west and northwest of Iran: a meta-analysis
title_short Pattern of drug resistant Mycobacterium tuberculosis in the west and northwest of Iran: a meta-analysis
title_sort pattern of drug resistant mycobacterium tuberculosis in the west and northwest of iran: a meta-analysis
topic Meta-Analysis Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132330/
https://www.ncbi.nlm.nih.gov/pubmed/37124845
http://dx.doi.org/10.18502/ijm.v14i3.9754
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