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Candida auris: outbreak fungal pathogen in COVID-19 pandemic: a systematic review and meta-analysis
BACKGROUND AND OBJECTIVES: Candida auris (C. auris) is the first fungal pathogen considered a global health threat. Because, C. auris is associated with multidrug resistance and associated diseases such as diabetes, sepsis, lung and kidney disease. This study investigated the prevalence and mortalit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Tehran University of Medical Sciences
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132344/ https://www.ncbi.nlm.nih.gov/pubmed/37124855 http://dx.doi.org/10.18502/ijm.v14i3.9753 |
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author | Bagheri Lankarani, Kamran Akbari, Maryam Tabrizi, Reza Vali, Mohebat Sekhavati, Eghbal Heydari, Seyed Taghi Khodadadi, Hossein Ahmadizar, Fariba |
author_facet | Bagheri Lankarani, Kamran Akbari, Maryam Tabrizi, Reza Vali, Mohebat Sekhavati, Eghbal Heydari, Seyed Taghi Khodadadi, Hossein Ahmadizar, Fariba |
author_sort | Bagheri Lankarani, Kamran |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Candida auris (C. auris) is the first fungal pathogen considered a global health threat. Because, C. auris is associated with multidrug resistance and associated diseases such as diabetes, sepsis, lung and kidney disease. This study investigated the prevalence and mortality of C. auris infection during Covid-19 pandemic. MATERIALS AND METHODS: Databases were searched for peer-reviewed articles published in the English language up to Jan 18, 2022. Heterogeneity across studies was evaluated using Cochrane’s Q test and the I2 index. The pooled point prevalences and their corresponding 95% confidence intervals (CIs) were estimated usingthe random-effects model. RESULTS: In our meta-analysis, 11 eligible articles were included. The total pooled prevalence estimation of C. auris infection among COVID-19 patients was 13% (95% CI: 8%, 19%). The estimated pooled mortality rate of C. auris infection was 37% (95% CI: 15%, 61%). In terms of specific conditions, the pooled risk of mortality was higher in people with diabetes 65% (95% CI: 0.45%, 83%), in cases with >21 days admission inintensive care unit (ICU) 44% (95% CI: 21%, 0.68%), and after receiving steroids 43% (95% CI: 18%, 69%). CONCLUSION: Our study highlights the high prevalence rate of C. auris infection, particularly among people with a history of metabolic disorders. |
format | Online Article Text |
id | pubmed-10132344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-101323442023-04-27 Candida auris: outbreak fungal pathogen in COVID-19 pandemic: a systematic review and meta-analysis Bagheri Lankarani, Kamran Akbari, Maryam Tabrizi, Reza Vali, Mohebat Sekhavati, Eghbal Heydari, Seyed Taghi Khodadadi, Hossein Ahmadizar, Fariba Iran J Microbiol Review Article BACKGROUND AND OBJECTIVES: Candida auris (C. auris) is the first fungal pathogen considered a global health threat. Because, C. auris is associated with multidrug resistance and associated diseases such as diabetes, sepsis, lung and kidney disease. This study investigated the prevalence and mortality of C. auris infection during Covid-19 pandemic. MATERIALS AND METHODS: Databases were searched for peer-reviewed articles published in the English language up to Jan 18, 2022. Heterogeneity across studies was evaluated using Cochrane’s Q test and the I2 index. The pooled point prevalences and their corresponding 95% confidence intervals (CIs) were estimated usingthe random-effects model. RESULTS: In our meta-analysis, 11 eligible articles were included. The total pooled prevalence estimation of C. auris infection among COVID-19 patients was 13% (95% CI: 8%, 19%). The estimated pooled mortality rate of C. auris infection was 37% (95% CI: 15%, 61%). In terms of specific conditions, the pooled risk of mortality was higher in people with diabetes 65% (95% CI: 0.45%, 83%), in cases with >21 days admission inintensive care unit (ICU) 44% (95% CI: 21%, 0.68%), and after receiving steroids 43% (95% CI: 18%, 69%). CONCLUSION: Our study highlights the high prevalence rate of C. auris infection, particularly among people with a history of metabolic disorders. Tehran University of Medical Sciences 2022-06 /pmc/articles/PMC10132344/ /pubmed/37124855 http://dx.doi.org/10.18502/ijm.v14i3.9753 Text en Copyright © 2022 The Authors. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Review Article Bagheri Lankarani, Kamran Akbari, Maryam Tabrizi, Reza Vali, Mohebat Sekhavati, Eghbal Heydari, Seyed Taghi Khodadadi, Hossein Ahmadizar, Fariba Candida auris: outbreak fungal pathogen in COVID-19 pandemic: a systematic review and meta-analysis |
title | Candida auris: outbreak fungal pathogen in COVID-19 pandemic: a systematic review and meta-analysis |
title_full | Candida auris: outbreak fungal pathogen in COVID-19 pandemic: a systematic review and meta-analysis |
title_fullStr | Candida auris: outbreak fungal pathogen in COVID-19 pandemic: a systematic review and meta-analysis |
title_full_unstemmed | Candida auris: outbreak fungal pathogen in COVID-19 pandemic: a systematic review and meta-analysis |
title_short | Candida auris: outbreak fungal pathogen in COVID-19 pandemic: a systematic review and meta-analysis |
title_sort | candida auris: outbreak fungal pathogen in covid-19 pandemic: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132344/ https://www.ncbi.nlm.nih.gov/pubmed/37124855 http://dx.doi.org/10.18502/ijm.v14i3.9753 |
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