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Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM

The recognition of antigenic peptide-MHC (pMHC) molecules by T-cell receptors (TCR) initiates the T-cell mediated immune response. Structural characterization is key for understanding the specificity of TCR-pMHC interactions and informing the development of therapeutics. Despite the rapid rise of si...

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Detalles Bibliográficos
Autores principales:	Saotome, Kei, Dudgeon, Drew, Colotti, Kiersten, Moore, Michael J., Jones, Jennifer, Zhou, Yi, Rafique, Ashique, Yancopoulos, George D., Murphy, Andrew J., Lin, John C., Olson, William C., Franklin, Matthew C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132440/ https://www.ncbi.nlm.nih.gov/pubmed/37100770 http://dx.doi.org/10.1038/s41467-023-37532-7

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