Cargando…

A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease

BACKGROUND: Diffuse midline glioma (DMG) is an aggressive pediatric central nervous system tumor with strong metastatic potential. As localized treatment of the primary tumor improves, metastatic disease is becoming a more important factor in treatment. We hypothesized that we could model craniospin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knox, Aaron J., Van Court, Benjamin, Oweida, Ayman, Barsh, Elinor, DeSisto, John, Flannery, Patrick, Lemma, Rakeb, Chatwin, Hannah, Vibhakar, Rajeev, Dorris, Kathleen, Serkova, Natalie J., Karam, Sana D., Gilani, Ahmed, Green, Adam L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132465/ https://www.ncbi.nlm.nih.gov/pubmed/37124531 http://dx.doi.org/10.3389/fonc.2023.1105395

Ejemplares similares

DIPG-42. TOWARD MULTIMODALITY THERAPY FOR DIPG/DMG: DEVELOPMENT AND INVESTIGATION OF CRANIOSPINAL IRRADIATION AND CONVECTION-ENHANCED DELIVERY PDX MODELS
por: Knox, Aaron J, et al.
Publicado: (2020)

MODL-31. RADIATION-DERIVED TREATMENT-RESISTANT PDX AND CELL CULTURE MODELS RECAPITULATE THE CHARACTERISTICS OF MATCHED PRIMARY/RECURRENT PEDIATRIC HIGH-GRADE GLIOMA
por: Knox, Aaron J, et al.
Publicado: (2020)

DIPG-79. H3K27M INDUCES EPIGENETIC AND ONCOGENIC CHANGES THAT ARE PARTIALLY REVERSED BY SMALL MOLECULE AURORA KINASE B/C INHIBITION
por: Chatwin, Hannah, et al.
Publicado: (2020)

HGG-25. PRMT5 PROMOTES TUMOR GROWTH BY MAINTAINING STEMNESS OF PEDIATRIC HIGH-GRADE GLIOMA CELLS
por: DeSisto, John, et al.
Publicado: (2021)

Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine
por: Green, Adam L, et al.
Publicado: (2020)

LGG-13. PILOCYTIC ASTROCYTOMAS WITH NOVEL BRAF FUSIONS DEMONSTRATE MAPK PATHWAY ACTIVATION
por: Chatwin, Hannah, et al.
Publicado: (2021)

HGG-20. PRMT5 promotes the formation and growth of pediatric high-grade glioma by maintaining tumor stem cell populations
por: DeSisto, John, et al.
Publicado: (2022)

MODL-31. Novel in vivo models of post-radiation recurrent pediatric high-grade glioma show increased susceptibility to MAPK inhibition
por: Knox, Aaron, et al.
Publicado: (2022)

DIPG-57. TESTING FOR SYNERGY AMONG RADIATION AND HIGHLY CLINICALLY RELEVANT CHEMOTHERAPEUTIC AGENTS IN PATIENT-DERIVED MODELS OF DIFFUSE MIDLINE GLIOMA
por: Slade, Mathew, et al.
Publicado: (2023)

Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma
por: Flannery, Patrick C., et al.
Publicado: (2018)

DIPG-34. SUPER ELONGATION COMPLEX AS A TARGETABLE DEPENDENCY IN H3K27M+ DIFFUSE MIDLINE GLIOMA
por: Dahl, Nathan, et al.
Publicado: (2020)

BPTF Regulates Growth of Adult and Pediatric High-Grade Glioma through the MYC Pathway
por: Green, Adam L., et al.
Publicado: (2019)

Foramen magnum meningioma approached by the midline subtonsilar approach – Revisiting Cushing’s classification of craniospinal meningiomas
por: da Silveira, Roberto Leal, et al.
Publicado: (2023)

Overcoming Resistance to Combination Radiation-Immunotherapy: A Focus on Contributing Pathways Within the Tumor Microenvironment
por: Darragh, Laurel B., et al.
Publicado: (2019)

HGG-18. SINGLE CELL RNA-SEQ ANALYSIS OF PEDIATRIC HIGH-GRADE GLIOMA PATIENT SAMPLES IDENTIFIES COMMON GLIAL AND IMMUNE CELL TYPES THAT HELP TO EXPLAIN HETEROGENEITY AND TUMORIGENESIS
por: DeSisto, John, et al.
Publicado: (2023)

HGG-57. WHOLE-GENOME SEQUENCING, METHYLATION ANALYSIS, AND SINGLE-CELL RNA-SEQ DEFINE UNIQUE CHARACTERISTICS OF PEDIATRIC TREATMENT-INDUCED HIGH-GRADE GLIOMA AND SUGGEST ONCOGENIC MECHANISMS
por: Lucas, John, et al.
Publicado: (2020)

MBRS-26. CDK7 MEDIATED TRANSCRIPTIONAL PROCESSIVITY OF DNA REPAIR NETWORKS REGULATES SENSITIVITY TO RADIATION IN MYC DRIVEN MEDULLOBLASTOMA
por: Veo, Bethany, et al.
Publicado: (2020)

DIPG-32. PRECLINICAL TESTING OF THE EFFICACY AND SAFETY OF CRISPR/CAS9 GENE EDITED CAR-T CELL THERAPY FOR DIFFUSE MIDLINE GLIOMA (DMG)
por: Balakrishnan, Ilango, et al.
Publicado: (2023)

Combined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma
por: Bhatia, Shilpa, et al.
Publicado: (2017)

Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation
por: Meyer, Jeffrey J, et al.
Publicado: (2006)

Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
por: DeSisto, John, et al.
Publicado: (2021)

Uncommon presentation of craniospinal tuberculosis
por: Abdulrabu, Mohammed, et al.
Publicado: (2021)

Preclinical Models of Craniospinal Irradiation for Medulloblastoma
por: Stripay, Jennifer L., et al.
Publicado: (2020)

HGG-12. Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy
por: Walker, Faye, et al.
Publicado: (2022)

XRT-06. RAPID PTEFB-DEPENDENT TRANSCRIPTIONAL REORGANIZATION UNDERPINS THE GLIOMA ADAPTIVE RESPONSE TO RADIOTHERAPY
por: Walker, Faye, et al.
Publicado: (2023)

Surgical Management of Acute Abdomen in Adult Patients: Experience from a Private Hospital in Addis Ababa, Ethiopia
por: Ademe, Yonas, et al.
Publicado: (2022)

Validation of an automated contouring and treatment planning tool for pediatric craniospinal radiation therapy
por: Hernandez, Soleil, et al.
Publicado: (2023)

Recurrent craniospinal epidermoid: A case report
por: Shah, Abhidha, et al.
Publicado: (2016)

Practical dose delivery verification of craniospinal IMRT
por: Lee, Young K, et al.
Publicado: (2015)

Clinical Implementation of Robust Optimization for Craniospinal Irradiation
por: Tasson, Alexandria, et al.
Publicado: (2018)

DIPG-56. Development and application of a novel antibody against CD99 as a therapeutic strategy in Diffuse Midline Glioma
por: Venkataraman, Sujatha, et al.
Publicado: (2022)

Recurrent craniospinal subarachnoid hemorrhage in cerebral amyloid angiopathy
por: Alexander, Mathew, et al.
Publicado: (2013)

The Role of the Craniocervical Junction in Craniospinal Hydrodynamics and Neurodegenerative Conditions
por: Flanagan, Michael F.
Publicado: (2015)

Method to plan, administer, and verify supine craniospinal irradiation
por: Michalski, Jeff M., et al.
Publicado: (2002)

A Rare Case of Simultaneous Multifocal Craniospinal Hemangiopericytomas
por: Singh, Harnarayan, et al.
Publicado: (2018)

Management Strategies and Outcomes for VHL-related Craniospinal Hemangioblastomas
por: Ordookhanian, Christ, et al.
Publicado: (2017)

GCT-35. SALVAGE CRANIOSPINAL IRRADIATION FOR RECURRENT GERMINOMAS
por: Kanamori, Masayuki, et al.
Publicado: (2020)

Practical aspects of the application of helical tomotherapy for craniospinal irradiation
por: Lee, Joongyo, et al.
Publicado: (2021)

Pulmonary toxicity of craniospinal irradiation using helical tomotherapy
por: Lee, Joongyo, et al.
Publicado: (2022)

DIPG-61. Preclinical efficacy of combined radiotherapy with venetoclax treatment in targeting diffuse midline gliomas
por: Madhavan, Krishna, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d9j6rtshjtj35ph2c0qodk396h