Cargando…

Cohort study of the mortality among patients in New York City with tuberculosis and COVID-19, March 2020 to June 2022

Both tuberculosis (TB) and COVID-19 can affect the respiratory system, and early findings suggest co-occurrence of these infectious diseases can result in elevated mortality. A retrospective cohort of patients who were diagnosed with TB and COVID-19 concurrently (within 120 days) between March 2020...

Descripción completa

Detalles Bibliográficos
Autores principales: Easton, Alice V., Salerno, Marco M, Trieu, Lisa, Humphrey, Erica, Kaba, Fanta, Macaraig, Michelle, Dworkin, Felicia, Nilsen, Diana M., Burzynski, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132536/
https://www.ncbi.nlm.nih.gov/pubmed/37186110
http://dx.doi.org/10.1371/journal.pgph.0001758
_version_ 1785031402085941248
author Easton, Alice V.
Salerno, Marco M
Trieu, Lisa
Humphrey, Erica
Kaba, Fanta
Macaraig, Michelle
Dworkin, Felicia
Nilsen, Diana M.
Burzynski, Joseph
author_facet Easton, Alice V.
Salerno, Marco M
Trieu, Lisa
Humphrey, Erica
Kaba, Fanta
Macaraig, Michelle
Dworkin, Felicia
Nilsen, Diana M.
Burzynski, Joseph
author_sort Easton, Alice V.
collection PubMed
description Both tuberculosis (TB) and COVID-19 can affect the respiratory system, and early findings suggest co-occurrence of these infectious diseases can result in elevated mortality. A retrospective cohort of patients who were diagnosed with TB and COVID-19 concurrently (within 120 days) between March 2020 and June 2022 in New York City (NYC) was identified. This cohort was compared with a cohort of patients diagnosed with TB-alone during the same period in terms of demographic information, clinical characteristics, and mortality. Cox proportional hazards regression was used to compare mortality between patient cohorts. One hundred and six patients with concurrent TB/COVID-19 were identified and compared with 902 patients with TB-alone. These two cohorts of patients were largely demographically and clinically similar. However, mortality was higher among patients with concurrent TB/COVID-19 in comparison to patients with TB-alone, even after controlling for age and sex (hazard ratio 2.62, 95% Confidence Interval 1.66–4.13). Nearly one in three (22/70, 31%) patients with concurrent TB/COVID-19 aged 45 and above died during the study period. These results suggest that TB patients with concurrent COVID-19 were at high risk for mortality. It is important that, as a high-risk group, patients with TB are prioritized for resources to quickly diagnose and treat COVID-19, and provided with tools and information to protect themselves from COVID-19.
format Online
Article
Text
id pubmed-10132536
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-101325362023-04-27 Cohort study of the mortality among patients in New York City with tuberculosis and COVID-19, March 2020 to June 2022 Easton, Alice V. Salerno, Marco M Trieu, Lisa Humphrey, Erica Kaba, Fanta Macaraig, Michelle Dworkin, Felicia Nilsen, Diana M. Burzynski, Joseph PLOS Glob Public Health Research Article Both tuberculosis (TB) and COVID-19 can affect the respiratory system, and early findings suggest co-occurrence of these infectious diseases can result in elevated mortality. A retrospective cohort of patients who were diagnosed with TB and COVID-19 concurrently (within 120 days) between March 2020 and June 2022 in New York City (NYC) was identified. This cohort was compared with a cohort of patients diagnosed with TB-alone during the same period in terms of demographic information, clinical characteristics, and mortality. Cox proportional hazards regression was used to compare mortality between patient cohorts. One hundred and six patients with concurrent TB/COVID-19 were identified and compared with 902 patients with TB-alone. These two cohorts of patients were largely demographically and clinically similar. However, mortality was higher among patients with concurrent TB/COVID-19 in comparison to patients with TB-alone, even after controlling for age and sex (hazard ratio 2.62, 95% Confidence Interval 1.66–4.13). Nearly one in three (22/70, 31%) patients with concurrent TB/COVID-19 aged 45 and above died during the study period. These results suggest that TB patients with concurrent COVID-19 were at high risk for mortality. It is important that, as a high-risk group, patients with TB are prioritized for resources to quickly diagnose and treat COVID-19, and provided with tools and information to protect themselves from COVID-19. Public Library of Science 2023-04-26 /pmc/articles/PMC10132536/ /pubmed/37186110 http://dx.doi.org/10.1371/journal.pgph.0001758 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Easton, Alice V.
Salerno, Marco M
Trieu, Lisa
Humphrey, Erica
Kaba, Fanta
Macaraig, Michelle
Dworkin, Felicia
Nilsen, Diana M.
Burzynski, Joseph
Cohort study of the mortality among patients in New York City with tuberculosis and COVID-19, March 2020 to June 2022
title Cohort study of the mortality among patients in New York City with tuberculosis and COVID-19, March 2020 to June 2022
title_full Cohort study of the mortality among patients in New York City with tuberculosis and COVID-19, March 2020 to June 2022
title_fullStr Cohort study of the mortality among patients in New York City with tuberculosis and COVID-19, March 2020 to June 2022
title_full_unstemmed Cohort study of the mortality among patients in New York City with tuberculosis and COVID-19, March 2020 to June 2022
title_short Cohort study of the mortality among patients in New York City with tuberculosis and COVID-19, March 2020 to June 2022
title_sort cohort study of the mortality among patients in new york city with tuberculosis and covid-19, march 2020 to june 2022
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132536/
https://www.ncbi.nlm.nih.gov/pubmed/37186110
http://dx.doi.org/10.1371/journal.pgph.0001758
work_keys_str_mv AT eastonalicev cohortstudyofthemortalityamongpatientsinnewyorkcitywithtuberculosisandcovid19march2020tojune2022
AT salernomarcom cohortstudyofthemortalityamongpatientsinnewyorkcitywithtuberculosisandcovid19march2020tojune2022
AT trieulisa cohortstudyofthemortalityamongpatientsinnewyorkcitywithtuberculosisandcovid19march2020tojune2022
AT humphreyerica cohortstudyofthemortalityamongpatientsinnewyorkcitywithtuberculosisandcovid19march2020tojune2022
AT kabafanta cohortstudyofthemortalityamongpatientsinnewyorkcitywithtuberculosisandcovid19march2020tojune2022
AT macaraigmichelle cohortstudyofthemortalityamongpatientsinnewyorkcitywithtuberculosisandcovid19march2020tojune2022
AT dworkinfelicia cohortstudyofthemortalityamongpatientsinnewyorkcitywithtuberculosisandcovid19march2020tojune2022
AT nilsendianam cohortstudyofthemortalityamongpatientsinnewyorkcitywithtuberculosisandcovid19march2020tojune2022
AT burzynskijoseph cohortstudyofthemortalityamongpatientsinnewyorkcitywithtuberculosisandcovid19march2020tojune2022