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Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors
A member of THIK (two pore domain halothane-inhibited K(+)) channels, THIK-1, was reported as a target of Gi/o-coupled receptors (Gi/o-Rs) in neurons and microglia. We confirmed that in HEK293T cells the THIK-1 channel is activated by Gi/o-Rs and found that Gq-coupled receptors (Gq-Rs) also activate...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132538/ https://www.ncbi.nlm.nih.gov/pubmed/37099539 http://dx.doi.org/10.1371/journal.pone.0284962 |