Cargando…
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes
Nononcogenic somatic mutations are thought to be uncommon and inconsequential. To test this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine blood whole genomes from 37 cohorts and identified 7131 non-missense somatic mutations that are recurrently muta...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132750/ https://www.ncbi.nlm.nih.gov/pubmed/37126548 http://dx.doi.org/10.1126/sciadv.abm4945 |
| _version_ | 1785031455829655552 |
|---|---|
| author | Weinstock, Joshua S. Laurie, Cecelia A. Broome, Jai G. Taylor, Kent D. Guo, Xiuqing Shuldiner, Alan R. O’Connell, Jeffrey R. Lewis, Joshua P. Boerwinkle, Eric Barnes, Kathleen C. Chami, Nathalie Kenny, Eimear E. Loos, Ruth J. F. Fornage, Myriam Redline, Susan Cade, Brian E. Gilliland, Frank D. Chen, Zhanghua Gauderman, W. James Kumar, Rajesh Grammer, Leslie Schleimer, Robert P. Psaty, Bruce M. Bis, Joshua C. Brody, Jennifer A. Silverman, Edwin K. Yun, Jeong H. Qiao, Dandi Weiss, Scott T. Lasky-Su, Jessica DeMeo, Dawn L. Palmer, Nicholette D. Freedman, Barry I. Bowden, Donald W. Cho, Michael H. Vasan, Ramachandran S. Johnson, Andrew D. Yanek, Lisa R. Becker, Lewis C. Kardia, Sharon He, Jiang Kaplan, Robert Heckbert, Susan R. Smith, Nicholas L. Wiggins, Kerri L. Arnett, Donna K. Irvin, Marguerite R. Tiwari, Hemant Correa, Adolfo Raffield, Laura M. Gao, Yan de Andrade, Mariza Rotter, Jerome I. Rich, Stephen S. Manichaikul, Ani W. Konkle, Barbara A. Johnsen, Jill M. Wheeler, Marsha M. Custer, Brian S. Duggirala, Ravindranath Curran, Joanne E. Blangero, John Gui, Hongsheng Xiao, Shujie Williams, L. Keoki Meyers, Deborah A. Li, Xingnan Ortega, Victor McGarvey, Stephen Gu, C. Charles Chen, Yii-Der Ida Lee, Wen-Jane Shoemaker, M. Benjamin Darbar, Dawood Roden, Dan Albert, Christine Kooperberg, Charles Desai, Pinkal Blackwell, Thomas W. Abecasis, Goncalo R. Smith, Albert V. Kang, Hyun M. Mathias, Rasika Natarajan, Pradeep Jaiswal, Siddhartha Reiner, Alexander P. Bick, Alexander G. |
| author_facet | Weinstock, Joshua S. Laurie, Cecelia A. Broome, Jai G. Taylor, Kent D. Guo, Xiuqing Shuldiner, Alan R. O’Connell, Jeffrey R. Lewis, Joshua P. Boerwinkle, Eric Barnes, Kathleen C. Chami, Nathalie Kenny, Eimear E. Loos, Ruth J. F. Fornage, Myriam Redline, Susan Cade, Brian E. Gilliland, Frank D. Chen, Zhanghua Gauderman, W. James Kumar, Rajesh Grammer, Leslie Schleimer, Robert P. Psaty, Bruce M. Bis, Joshua C. Brody, Jennifer A. Silverman, Edwin K. Yun, Jeong H. Qiao, Dandi Weiss, Scott T. Lasky-Su, Jessica DeMeo, Dawn L. Palmer, Nicholette D. Freedman, Barry I. Bowden, Donald W. Cho, Michael H. Vasan, Ramachandran S. Johnson, Andrew D. Yanek, Lisa R. Becker, Lewis C. Kardia, Sharon He, Jiang Kaplan, Robert Heckbert, Susan R. Smith, Nicholas L. Wiggins, Kerri L. Arnett, Donna K. Irvin, Marguerite R. Tiwari, Hemant Correa, Adolfo Raffield, Laura M. Gao, Yan de Andrade, Mariza Rotter, Jerome I. Rich, Stephen S. Manichaikul, Ani W. Konkle, Barbara A. Johnsen, Jill M. Wheeler, Marsha M. Custer, Brian S. Duggirala, Ravindranath Curran, Joanne E. Blangero, John Gui, Hongsheng Xiao, Shujie Williams, L. Keoki Meyers, Deborah A. Li, Xingnan Ortega, Victor McGarvey, Stephen Gu, C. Charles Chen, Yii-Der Ida Lee, Wen-Jane Shoemaker, M. Benjamin Darbar, Dawood Roden, Dan Albert, Christine Kooperberg, Charles Desai, Pinkal Blackwell, Thomas W. Abecasis, Goncalo R. Smith, Albert V. Kang, Hyun M. Mathias, Rasika Natarajan, Pradeep Jaiswal, Siddhartha Reiner, Alexander P. Bick, Alexander G. |
| author_sort | Weinstock, Joshua S. |
| collection | PubMed |
| description | Nononcogenic somatic mutations are thought to be uncommon and inconsequential. To test this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine blood whole genomes from 37 cohorts and identified 7131 non-missense somatic mutations that are recurrently mutated in at least 50 individuals. These recurrent non-missense somatic mutations (RNMSMs) are not clearly explained by other clonal phenomena such as clonal hematopoiesis. RNMSM prevalence increased with age, with an average 50-year-old having 27 RNMSMs. Inherited germline variation associated with RNMSM acquisition. These variants were found in genes involved in adaptive immune function, proinflammatory cytokine production, and lymphoid lineage commitment. In addition, the presence of eight specific RNMSMs associated with blood cell traits at effect sizes comparable to Mendelian genetic mutations. Overall, we found that somatic mutations in blood are an unexpectedly common phenomenon with ancestry-specific determinants and human health consequences. |
| format | Online Article Text |
| id | pubmed-10132750 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | American Association for the Advancement of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-101327502023-04-27 The genetic determinants of recurrent somatic mutations in 43,693 blood genomes Weinstock, Joshua S. Laurie, Cecelia A. Broome, Jai G. Taylor, Kent D. Guo, Xiuqing Shuldiner, Alan R. O’Connell, Jeffrey R. Lewis, Joshua P. Boerwinkle, Eric Barnes, Kathleen C. Chami, Nathalie Kenny, Eimear E. Loos, Ruth J. F. Fornage, Myriam Redline, Susan Cade, Brian E. Gilliland, Frank D. Chen, Zhanghua Gauderman, W. James Kumar, Rajesh Grammer, Leslie Schleimer, Robert P. Psaty, Bruce M. Bis, Joshua C. Brody, Jennifer A. Silverman, Edwin K. Yun, Jeong H. Qiao, Dandi Weiss, Scott T. Lasky-Su, Jessica DeMeo, Dawn L. Palmer, Nicholette D. Freedman, Barry I. Bowden, Donald W. Cho, Michael H. Vasan, Ramachandran S. Johnson, Andrew D. Yanek, Lisa R. Becker, Lewis C. Kardia, Sharon He, Jiang Kaplan, Robert Heckbert, Susan R. Smith, Nicholas L. Wiggins, Kerri L. Arnett, Donna K. Irvin, Marguerite R. Tiwari, Hemant Correa, Adolfo Raffield, Laura M. Gao, Yan de Andrade, Mariza Rotter, Jerome I. Rich, Stephen S. Manichaikul, Ani W. Konkle, Barbara A. Johnsen, Jill M. Wheeler, Marsha M. Custer, Brian S. Duggirala, Ravindranath Curran, Joanne E. Blangero, John Gui, Hongsheng Xiao, Shujie Williams, L. Keoki Meyers, Deborah A. Li, Xingnan Ortega, Victor McGarvey, Stephen Gu, C. Charles Chen, Yii-Der Ida Lee, Wen-Jane Shoemaker, M. Benjamin Darbar, Dawood Roden, Dan Albert, Christine Kooperberg, Charles Desai, Pinkal Blackwell, Thomas W. Abecasis, Goncalo R. Smith, Albert V. Kang, Hyun M. Mathias, Rasika Natarajan, Pradeep Jaiswal, Siddhartha Reiner, Alexander P. Bick, Alexander G. Sci Adv Biomedicine and Life Sciences Nononcogenic somatic mutations are thought to be uncommon and inconsequential. To test this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine blood whole genomes from 37 cohorts and identified 7131 non-missense somatic mutations that are recurrently mutated in at least 50 individuals. These recurrent non-missense somatic mutations (RNMSMs) are not clearly explained by other clonal phenomena such as clonal hematopoiesis. RNMSM prevalence increased with age, with an average 50-year-old having 27 RNMSMs. Inherited germline variation associated with RNMSM acquisition. These variants were found in genes involved in adaptive immune function, proinflammatory cytokine production, and lymphoid lineage commitment. In addition, the presence of eight specific RNMSMs associated with blood cell traits at effect sizes comparable to Mendelian genetic mutations. Overall, we found that somatic mutations in blood are an unexpectedly common phenomenon with ancestry-specific determinants and human health consequences. American Association for the Advancement of Science 2023-04-26 /pmc/articles/PMC10132750/ /pubmed/37126548 http://dx.doi.org/10.1126/sciadv.abm4945 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
| spellingShingle | Biomedicine and Life Sciences Weinstock, Joshua S. Laurie, Cecelia A. Broome, Jai G. Taylor, Kent D. Guo, Xiuqing Shuldiner, Alan R. O’Connell, Jeffrey R. Lewis, Joshua P. Boerwinkle, Eric Barnes, Kathleen C. Chami, Nathalie Kenny, Eimear E. Loos, Ruth J. F. Fornage, Myriam Redline, Susan Cade, Brian E. Gilliland, Frank D. Chen, Zhanghua Gauderman, W. James Kumar, Rajesh Grammer, Leslie Schleimer, Robert P. Psaty, Bruce M. Bis, Joshua C. Brody, Jennifer A. Silverman, Edwin K. Yun, Jeong H. Qiao, Dandi Weiss, Scott T. Lasky-Su, Jessica DeMeo, Dawn L. Palmer, Nicholette D. Freedman, Barry I. Bowden, Donald W. Cho, Michael H. Vasan, Ramachandran S. Johnson, Andrew D. Yanek, Lisa R. Becker, Lewis C. Kardia, Sharon He, Jiang Kaplan, Robert Heckbert, Susan R. Smith, Nicholas L. Wiggins, Kerri L. Arnett, Donna K. Irvin, Marguerite R. Tiwari, Hemant Correa, Adolfo Raffield, Laura M. Gao, Yan de Andrade, Mariza Rotter, Jerome I. Rich, Stephen S. Manichaikul, Ani W. Konkle, Barbara A. Johnsen, Jill M. Wheeler, Marsha M. Custer, Brian S. Duggirala, Ravindranath Curran, Joanne E. Blangero, John Gui, Hongsheng Xiao, Shujie Williams, L. Keoki Meyers, Deborah A. Li, Xingnan Ortega, Victor McGarvey, Stephen Gu, C. Charles Chen, Yii-Der Ida Lee, Wen-Jane Shoemaker, M. Benjamin Darbar, Dawood Roden, Dan Albert, Christine Kooperberg, Charles Desai, Pinkal Blackwell, Thomas W. Abecasis, Goncalo R. Smith, Albert V. Kang, Hyun M. Mathias, Rasika Natarajan, Pradeep Jaiswal, Siddhartha Reiner, Alexander P. Bick, Alexander G. The genetic determinants of recurrent somatic mutations in 43,693 blood genomes |
| title | The genetic determinants of recurrent somatic mutations in 43,693 blood genomes |
| title_full | The genetic determinants of recurrent somatic mutations in 43,693 blood genomes |
| title_fullStr | The genetic determinants of recurrent somatic mutations in 43,693 blood genomes |
| title_full_unstemmed | The genetic determinants of recurrent somatic mutations in 43,693 blood genomes |
| title_short | The genetic determinants of recurrent somatic mutations in 43,693 blood genomes |
| title_sort | genetic determinants of recurrent somatic mutations in 43,693 blood genomes |
| topic | Biomedicine and Life Sciences |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132750/ https://www.ncbi.nlm.nih.gov/pubmed/37126548 http://dx.doi.org/10.1126/sciadv.abm4945 |
| work_keys_str_mv | AT weinstockjoshuas thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT lauriececeliaa thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT broomejaig thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT taylorkentd thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT guoxiuqing thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT shuldineralanr thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT oconnelljeffreyr thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT lewisjoshuap thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT boerwinkleeric thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT barneskathleenc thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT chaminathalie thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kennyeimeare thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT loosruthjf thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT fornagemyriam thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT redlinesusan thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT cadebriane thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT gillilandfrankd thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT chenzhanghua thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT gaudermanwjames thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kumarrajesh thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT grammerleslie thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT schleimerrobertp thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT psatybrucem thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT bisjoshuac thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT brodyjennifera thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT silvermanedwink thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT yunjeongh thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT qiaodandi thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT weissscottt thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT laskysujessica thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT demeodawnl thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT palmernicholetted thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT freedmanbarryi thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT bowdendonaldw thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT chomichaelh thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT vasanramachandrans thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT johnsonandrewd thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT yaneklisar thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT beckerlewisc thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kardiasharon thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT hejiang thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kaplanrobert thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT heckbertsusanr thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT smithnicholasl thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT wigginskerril thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT arnettdonnak thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT irvinmargueriter thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT tiwarihemant thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT correaadolfo thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT raffieldlauram thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT gaoyan thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT deandrademariza thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT rotterjeromei thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT richstephens thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT manichaikulaniw thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT konklebarbaraa thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT johnsenjillm thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT wheelermarsham thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT custerbrians thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT duggiralaravindranath thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT curranjoannee thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT blangerojohn thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT guihongsheng thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT xiaoshujie thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT williamslkeoki thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT meyersdeboraha thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT lixingnan thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT ortegavictor thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT mcgarveystephen thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT guccharles thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT chenyiiderida thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT leewenjane thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT shoemakermbenjamin thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT darbardawood thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT rodendan thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT albertchristine thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kooperbergcharles thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT desaipinkal thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT blackwellthomasw thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT abecasisgoncalor thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT smithalbertv thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kanghyunm thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT mathiasrasika thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT natarajanpradeep thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT jaiswalsiddhartha thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT reineralexanderp thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT bickalexanderg thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT thegeneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT weinstockjoshuas geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT lauriececeliaa geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT broomejaig geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT taylorkentd geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT guoxiuqing geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT shuldineralanr geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT oconnelljeffreyr geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT lewisjoshuap geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT boerwinkleeric geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT barneskathleenc geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT chaminathalie geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kennyeimeare geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT loosruthjf geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT fornagemyriam geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT redlinesusan geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT cadebriane geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT gillilandfrankd geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT chenzhanghua geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT gaudermanwjames geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kumarrajesh geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT grammerleslie geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT schleimerrobertp geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT psatybrucem geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT bisjoshuac geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT brodyjennifera geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT silvermanedwink geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT yunjeongh geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT qiaodandi geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT weissscottt geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT laskysujessica geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT demeodawnl geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT palmernicholetted geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT freedmanbarryi geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT bowdendonaldw geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT chomichaelh geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT vasanramachandrans geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT johnsonandrewd geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT yaneklisar geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT beckerlewisc geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kardiasharon geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT hejiang geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kaplanrobert geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT heckbertsusanr geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT smithnicholasl geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT wigginskerril geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT arnettdonnak geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT irvinmargueriter geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT tiwarihemant geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT correaadolfo geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT raffieldlauram geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT gaoyan geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT deandrademariza geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT rotterjeromei geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT richstephens geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT manichaikulaniw geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT konklebarbaraa geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT johnsenjillm geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT wheelermarsham geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT custerbrians geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT duggiralaravindranath geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT curranjoannee geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT blangerojohn geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT guihongsheng geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT xiaoshujie geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT williamslkeoki geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT meyersdeboraha geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT lixingnan geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT ortegavictor geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT mcgarveystephen geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT guccharles geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT chenyiiderida geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT leewenjane geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT shoemakermbenjamin geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT darbardawood geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT rodendan geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT albertchristine geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kooperbergcharles geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT desaipinkal geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT blackwellthomasw geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT abecasisgoncalor geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT smithalbertv geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT kanghyunm geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT mathiasrasika geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT natarajanpradeep geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT jaiswalsiddhartha geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT reineralexanderp geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT bickalexanderg geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes AT geneticdeterminantsofrecurrentsomaticmutationsin43693bloodgenomes |