The genetic determinants of recurrent somatic mutations in 43,693 blood genomes

Nononcogenic somatic mutations are thought to be uncommon and inconsequential. To test this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine blood whole genomes from 37 cohorts and identified 7131 non-missense somatic mutations that are recurrently muta...

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Detalles Bibliográficos
Autores principales: Weinstock, Joshua S., Laurie, Cecelia A., Broome, Jai G., Taylor, Kent D., Guo, Xiuqing, Shuldiner, Alan R., O’Connell, Jeffrey R., Lewis, Joshua P., Boerwinkle, Eric, Barnes, Kathleen C., Chami, Nathalie, Kenny, Eimear E., Loos, Ruth J. F., Fornage, Myriam, Redline, Susan, Cade, Brian E., Gilliland, Frank D., Chen, Zhanghua, Gauderman, W. James, Kumar, Rajesh, Grammer, Leslie, Schleimer, Robert P., Psaty, Bruce M., Bis, Joshua C., Brody, Jennifer A., Silverman, Edwin K., Yun, Jeong H., Qiao, Dandi, Weiss, Scott T., Lasky-Su, Jessica, DeMeo, Dawn L., Palmer, Nicholette D., Freedman, Barry I., Bowden, Donald W., Cho, Michael H., Vasan, Ramachandran S., Johnson, Andrew D., Yanek, Lisa R., Becker, Lewis C., Kardia, Sharon, He, Jiang, Kaplan, Robert, Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Arnett, Donna K., Irvin, Marguerite R., Tiwari, Hemant, Correa, Adolfo, Raffield, Laura M., Gao, Yan, de Andrade, Mariza, Rotter, Jerome I., Rich, Stephen S., Manichaikul, Ani W., Konkle, Barbara A., Johnsen, Jill M., Wheeler, Marsha M., Custer, Brian S., Duggirala, Ravindranath, Curran, Joanne E., Blangero, John, Gui, Hongsheng, Xiao, Shujie, Williams, L. Keoki, Meyers, Deborah A., Li, Xingnan, Ortega, Victor, McGarvey, Stephen, Gu, C. Charles, Chen, Yii-Der Ida, Lee, Wen-Jane, Shoemaker, M. Benjamin, Darbar, Dawood, Roden, Dan, Albert, Christine, Kooperberg, Charles, Desai, Pinkal, Blackwell, Thomas W., Abecasis, Goncalo R., Smith, Albert V., Kang, Hyun M., Mathias, Rasika, Natarajan, Pradeep, Jaiswal, Siddhartha, Reiner, Alexander P., Bick, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132750/
https://www.ncbi.nlm.nih.gov/pubmed/37126548
http://dx.doi.org/10.1126/sciadv.abm4945

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