Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse

Aberrant AKT activation occurs in a number of cancers, metabolic syndrome, and immune disorders, making it an important target for the treatment of many diseases. To monitor spatial and temporal AKT activity in a live setting, we generated an Akt-FRET biosensor mouse that allows longitudinal assessm...

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Detalles Bibliográficos
Autores principales: Conway, James R. W., Warren, Sean C., Lee, Young-Kyung, McCulloch, Andrew T., Magenau, Astrid, Lee, Victoria, Metcalf, Xanthe L., Stoehr, Janett, Haigh, Katharina, Abdulkhalek, Lea, Guaman, Cristian S., Reed, Daniel A., Murphy, Kendelle J., Pereira, Brooke A., Mélénec, Pauline, Chambers, Cecilia, Latham, Sharissa L., Lenthall, Helen, Deenick, Elissa K., Ma, Yuanqing, Phan, Tri, Lim, Elgene, Joshua, Anthony M., Walters, Stacey, Grey, Shane T., Shi, Yan-Chuan, Zhang, Lei, Herzog, Herbert, Croucher, David R., Philp, Andy, Scheele, Colinda L.G.J., Herrmann, David, Sansom, Owen J., Morton, Jennifer P., Papa, Antonella, Haigh, Jody J., Nobis, Max, Timpson, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132756/
https://www.ncbi.nlm.nih.gov/pubmed/37126544
http://dx.doi.org/10.1126/sciadv.adf9063

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