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Oxidative DNA Damage by N(4)-hydroxycytidine, a Metabolite of the SARS-CoV-2 Antiviral Molnupiravir

Molnupiravir is an antiviral agent recently used for treating coronavirus disease 2019 (COVID-19). Here, we demonstrate that N(4)-hydroxycytidine (NHC), a molnupiravir metabolite, treated with cytidine deaminase (CDA) induced Cu(II)-mediated oxidative DNA damage in isolated DNA. A colorimetric assay...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Hatasu, Mori, Yurie, Ahmed, Sharif, Hirao, Yuichiro, Kato, Shinya, Kawanishi, Shosuke, Murata, Mariko, Oikawa, Shinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132762/ https://www.ncbi.nlm.nih.gov/pubmed/36461940 http://dx.doi.org/10.1093/infdis/jiac477

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