Research Progress of m(6)A RNA Methylation in Skin Diseases

N(6)-Methyladenosine (m(6)A) is the most common mRNA modification in eukaryotes and is a dynamically reversible posttranscriptional modification. The enzymes involved in m(6)A modification mainly include methyltransferases (writers), demethylases (erasers), and methylated readers (Readers). m(6)A modification is mainly catalyzed by m(6)A methyltransferase and removed by m(6)A demethylase. The modified RNA can be specifically recognized and bound by m(6)A recognition protein. This protein complex then mediates RNA splicing, maturation, nucleation, degradation, and translation. m(6)A also alters gene expression and regulates cellular processes such as self-renewal, differentiation, invasion, and apoptosis. An increasing body of evidence indicates that the m(6)A methylation modification process is closely related to the occurrence of various skin diseases. In this review, we discuss the role of m(6)A methylation in skin development and skin diseases including psoriasis, melanoma, and cutaneous squamous cell carcinoma.