Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus

Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor outcomes for patients with cancer(1–6). At present, it is unclear whether ecDNA is a later manifestation of genomic instability, or whether it can be...

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Detalles Bibliográficos
Autores principales: Luebeck, Jens, Ng, Alvin Wei Tian, Galipeau, Patricia C., Li, Xiaohong, Sanchez, Carissa A., Katz-Summercorn, Annalise C., Kim, Hoon, Jammula, Sriganesh, He, Yudou, Lippman, Scott M., Verhaak, Roel G. W., Maley, Carlo C., Alexandrov, Ludmil B., Reid, Brian J., Fitzgerald, Rebecca C., Paulson, Thomas G., Chang, Howard Y., Wu, Sihan, Bafna, Vineet, Mischel, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132967/
https://www.ncbi.nlm.nih.gov/pubmed/37046089
http://dx.doi.org/10.1038/s41586-023-05937-5

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