Ageing-associated changes in transcriptional elongation influence longevity

Physiological homeostasis becomes compromised during ageing, as a result of impairment of cellular processes, including transcription and RNA splicing(1–4). However, the molecular mechanisms leading to the loss of transcriptional fidelity are so far elusive, as are ways of preventing it. Here we pro...

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Detalles Bibliográficos
Autores principales: Debès, Cédric, Papadakis, Antonios, Grönke, Sebastian, Karalay, Özlem, Tain, Luke S., Mizi, Athanasia, Nakamura, Shuhei, Hahn, Oliver, Weigelt, Carina, Josipovic, Natasa, Zirkel, Anne, Brusius, Isabell, Sofiadis, Konstantinos, Lamprousi, Mantha, Lu, Yu-Xuan, Huang, Wenming, Esmaillie, Reza, Kubacki, Torsten, Späth, Martin R., Schermer, Bernhard, Benzing, Thomas, Müller, Roman-Ulrich, Antebi, Adam, Partridge, Linda, Papantonis, Argyris, Beyer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132977/
https://www.ncbi.nlm.nih.gov/pubmed/37046086
http://dx.doi.org/10.1038/s41586-023-05922-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132977/
https://www.ncbi.nlm.nih.gov/pubmed/37046086
http://dx.doi.org/10.1038/s41586-023-05922-y

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