Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors

To enhance the therapeutic index of T-cell engagers (TCEs), we engineered masked, precision-activated TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 (HER2) or epidermal growth factor receptor (EGFR)) and CD3. Unstructured XTEN polypeptide masks flank the N...

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Detalles Bibliográficos
Autores principales: Cattaruzza, Fiore, Nazeer, Ayesha, To, Milton, Hammond, Mikhail, Koski, Caitlin, Liu, Lucas Y., Pete Yeung, V., Rennerfeldt, Deena A., Henkensiefken, Angela, Fox, Michael, Lam, Sharon, Morrissey, Kari M., Lange, Zachary, Podust, Vladimir N., Derynck, Mika K., Irving, Bryan A., Schellenberger, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132983/
https://www.ncbi.nlm.nih.gov/pubmed/36997747
http://dx.doi.org/10.1038/s43018-023-00536-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132983/
https://www.ncbi.nlm.nih.gov/pubmed/36997747
http://dx.doi.org/10.1038/s43018-023-00536-9

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