Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism

Stromal myo-/fibroblasts (MFs) account for up to 30% of lamina propria cells in the normal human colon and their number is dramatically increased in colon cancer (CRC). Fibroblasts from cancers, also known as cancer-associated fibroblasts (CAFs), differ from normal colonic MF (N-MFs) and support tum...

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Autores principales: Villéger, Romain, Chulkina, Marina, Mifflin, Randy C., Powell, Don W., Pinchuk, Irina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2023
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132993/
https://www.ncbi.nlm.nih.gov/pubmed/37185128
http://dx.doi.org/10.18632/oncotarget.28399
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author Villéger, Romain
Chulkina, Marina
Mifflin, Randy C.
Powell, Don W.
Pinchuk, Irina V.
author_facet Villéger, Romain
Chulkina, Marina
Mifflin, Randy C.
Powell, Don W.
Pinchuk, Irina V.
author_sort Villéger, Romain
collection PubMed
description Stromal myo-/fibroblasts (MFs) account for up to 30% of lamina propria cells in the normal human colon and their number is dramatically increased in colon cancer (CRC). Fibroblasts from cancers, also known as cancer-associated fibroblasts (CAFs), differ from normal colonic MF (N-MFs) and support tumor-promoting inflammation, in part due to increased IL-6 secretion. In this editorial, we highlight recent data obtained regarding IL-6 regulation in colorectal cancer CAFs through vitamin A (retinol) metabolism, discuss current limitations in our understanding of the mechanisms leading to the CAF pro-inflammatory phenotype, and discuss potential approaches to target CAF retinoid metabolism during CRC treatment.
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spelling pubmed-101329932023-04-28 Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism Villéger, Romain Chulkina, Marina Mifflin, Randy C. Powell, Don W. Pinchuk, Irina V. Oncotarget Research Perspective Stromal myo-/fibroblasts (MFs) account for up to 30% of lamina propria cells in the normal human colon and their number is dramatically increased in colon cancer (CRC). Fibroblasts from cancers, also known as cancer-associated fibroblasts (CAFs), differ from normal colonic MF (N-MFs) and support tumor-promoting inflammation, in part due to increased IL-6 secretion. In this editorial, we highlight recent data obtained regarding IL-6 regulation in colorectal cancer CAFs through vitamin A (retinol) metabolism, discuss current limitations in our understanding of the mechanisms leading to the CAF pro-inflammatory phenotype, and discuss potential approaches to target CAF retinoid metabolism during CRC treatment. Impact Journals LLC 2023-04-26 /pmc/articles/PMC10132993/ /pubmed/37185128 http://dx.doi.org/10.18632/oncotarget.28399 Text en Copyright: © 2023 Villéger et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Villéger, Romain
Chulkina, Marina
Mifflin, Randy C.
Powell, Don W.
Pinchuk, Irina V.
Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism
title Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism
title_full Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism
title_fullStr Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism
title_full_unstemmed Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism
title_short Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism
title_sort disruption of retinol-mediated il-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin a metabolism
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132993/
https://www.ncbi.nlm.nih.gov/pubmed/37185128
http://dx.doi.org/10.18632/oncotarget.28399
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