Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction

Antiplatelet medication is standard of care in acute myocardial infarction (AMI). However, it may have obscured beneficial properties of the activated platelet secretome. We identify platelets as major source of a sphingosine-1-phosphate (S1P) burst during AMI, and find its magnitude to favorably as...

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Detalles Bibliográficos
Autores principales: Polzin, Amin, Dannenberg, Lisa, Benkhoff, Marcel, Barcik, Maike, Helten, Carolin, Mourikis, Philipp, Ahlbrecht, Samantha, Wildeis, Laura, Ziese, Justus, Zikeli, Dorothee, Metzen, Daniel, Hu, Hao, Baensch, Leonard, Schröder, Nathalie H., Keul, Petra, Weske, Sarah, Wollnitzke, Philipp, Duse, Dragos, Saffak, Süreyya, Cramer, Mareike, Bönner, Florian, Müller, Tina, Gräler, Markus H., Zeus, Tobias, Kelm, Malte, Levkau, Bodo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133218/
https://www.ncbi.nlm.nih.gov/pubmed/37100836
http://dx.doi.org/10.1038/s41467-023-38069-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133218/
https://www.ncbi.nlm.nih.gov/pubmed/37100836
http://dx.doi.org/10.1038/s41467-023-38069-5

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