The DNA damage response in advanced ovarian cancer: functional analysis combined with machine learning identifies signatures that correlate with chemotherapy sensitivity and patient outcome

BACKGROUND: Ovarian cancers are hallmarked by chromosomal instability. New therapies deliver improved patient outcomes in relevant phenotypes, however therapy resistance and poor long-term survival signal requirements for better patient preselection. An impaired DNA damage response (DDR) is a major...

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Detalles Bibliográficos
Autores principales: Walker, Thomas D. J., Faraahi, Zahra F., Price, Marcus J., Hawarden, Amy, Waddell, Caitlin A., Russell, Bryn, Jones, Dominique M., McCormick, Aiste, Gavrielides, N., Tyagi, S., Woodhouse, Laura C., Whalley, Bethany, Roberts, Connor, Crosbie, Emma J., Edmondson, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133248/
https://www.ncbi.nlm.nih.gov/pubmed/36810910
http://dx.doi.org/10.1038/s41416-023-02168-3

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