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Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction
Clinical studies on heart failure with mildly reduced left ventricular ejection fraction (HFmrEF) have gradually increased. However, studies on the prognostic differences between men and women among patients with HFmrEF are few, and no evidence on sex differences in such patients exists. Therefore,...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133291/ https://www.ncbi.nlm.nih.gov/pubmed/37100821 http://dx.doi.org/10.1038/s41598-023-33733-8 |
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author | Liu, Zhican Zhu, Yunlong Chen, Sihao Wu, Mingxin Huang, Haobo Peng, Ke Zhang, Lingling Zhao, Wenjiao Peng, Xin Li, Na Zhang, Hui Zhou, Yuying Peng, Yiqun Fan, Jie Zeng, Jianping |
author_facet | Liu, Zhican Zhu, Yunlong Chen, Sihao Wu, Mingxin Huang, Haobo Peng, Ke Zhang, Lingling Zhao, Wenjiao Peng, Xin Li, Na Zhang, Hui Zhou, Yuying Peng, Yiqun Fan, Jie Zeng, Jianping |
author_sort | Liu, Zhican |
collection | PubMed |
description | Clinical studies on heart failure with mildly reduced left ventricular ejection fraction (HFmrEF) have gradually increased. However, studies on the prognostic differences between men and women among patients with HFmrEF are few, and no evidence on sex differences in such patients exists. Therefore, we retrospectively assessed the data of patients with HFmrEF using propensity score-matched analysis (PSMA). A total of 1691 patients with HFmrEF were enrolled in the Outcome of Discharged HFmrEF Patients study (OUDI-HF study), which included 1095 men and 596 women. After propensity score matching, we compared the difference in cardiovascular (CV) events (cardiovascular death or heart failure readmission) and all-cause mortality at 90 days and 1 year after discharge between men and women using Kaplan–Meier analysis and Cox regression. After PSMA, men with HFmrEF were 2.2 times more likely to die at 90 days than women with HFmrEF [hazard ratio (HR) 1.88; 95% confidence interval (95% CI) 1.03–3.46; P = 0.041]. However, there was no difference in the 90-day CV events (HR 0.96; 95% CI 0.75–1.22; P = 0.718). Similarly, there was no difference in all-cause mortality (HR 1.16; 95% CI 0.81–1.65; P = 0.417) and CV events (HR 0.98; 95% CI 0.83–1.16; P = 0.817) between men and women after 1 year. Among the patients with HFmrEF, men had a higher 90-day risk of all-cause mortality than women after hospital discharge, and this risk disappeared after 1 year. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT05240118 (ESC Heart Failure. (2022). doi: 10.1002/ehf2.14044). |
format | Online Article Text |
id | pubmed-10133291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101332912023-04-28 Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction Liu, Zhican Zhu, Yunlong Chen, Sihao Wu, Mingxin Huang, Haobo Peng, Ke Zhang, Lingling Zhao, Wenjiao Peng, Xin Li, Na Zhang, Hui Zhou, Yuying Peng, Yiqun Fan, Jie Zeng, Jianping Sci Rep Article Clinical studies on heart failure with mildly reduced left ventricular ejection fraction (HFmrEF) have gradually increased. However, studies on the prognostic differences between men and women among patients with HFmrEF are few, and no evidence on sex differences in such patients exists. Therefore, we retrospectively assessed the data of patients with HFmrEF using propensity score-matched analysis (PSMA). A total of 1691 patients with HFmrEF were enrolled in the Outcome of Discharged HFmrEF Patients study (OUDI-HF study), which included 1095 men and 596 women. After propensity score matching, we compared the difference in cardiovascular (CV) events (cardiovascular death or heart failure readmission) and all-cause mortality at 90 days and 1 year after discharge between men and women using Kaplan–Meier analysis and Cox regression. After PSMA, men with HFmrEF were 2.2 times more likely to die at 90 days than women with HFmrEF [hazard ratio (HR) 1.88; 95% confidence interval (95% CI) 1.03–3.46; P = 0.041]. However, there was no difference in the 90-day CV events (HR 0.96; 95% CI 0.75–1.22; P = 0.718). Similarly, there was no difference in all-cause mortality (HR 1.16; 95% CI 0.81–1.65; P = 0.417) and CV events (HR 0.98; 95% CI 0.83–1.16; P = 0.817) between men and women after 1 year. Among the patients with HFmrEF, men had a higher 90-day risk of all-cause mortality than women after hospital discharge, and this risk disappeared after 1 year. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT05240118 (ESC Heart Failure. (2022). doi: 10.1002/ehf2.14044). Nature Publishing Group UK 2023-04-26 /pmc/articles/PMC10133291/ /pubmed/37100821 http://dx.doi.org/10.1038/s41598-023-33733-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Liu, Zhican Zhu, Yunlong Chen, Sihao Wu, Mingxin Huang, Haobo Peng, Ke Zhang, Lingling Zhao, Wenjiao Peng, Xin Li, Na Zhang, Hui Zhou, Yuying Peng, Yiqun Fan, Jie Zeng, Jianping Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction |
title | Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction |
title_full | Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction |
title_fullStr | Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction |
title_full_unstemmed | Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction |
title_short | Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction |
title_sort | sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133291/ https://www.ncbi.nlm.nih.gov/pubmed/37100821 http://dx.doi.org/10.1038/s41598-023-33733-8 |
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