Cargando…

Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure

Mitochondrial dysfunction, causing increased reactive oxygen species (ROS) production, is a molecular feature of heart failure (HF). A defective antioxidant response and mitophagic flux were reported in circulating leucocytes of patients with chronic HF and reduced ejection fraction (HFrEF). Atrial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raffa, Salvatore, Forte, Maurizio, Gallo, Giovanna, Ranieri, Danilo, Marchitti, Simona, Magrì, Damiano, Testa, Marco, Stanzione, Rosita, Bianchi, Franca, Cotugno, Maria, Fiori, Emiliano, Visco, Vincenzo, Sciarretta, Sebastiano, Volpe, Massimo, Rubattu, Speranza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133375/ https://www.ncbi.nlm.nih.gov/pubmed/37099206 http://dx.doi.org/10.1007/s00018-023-04777-w

Ejemplares similares

Functional Role of Natriuretic Peptides in Risk Assessment and Prognosis of Patients with Mitral Regurgitation
por: Gallo, Giovanna, et al.
Publicado: (2020)

The T2238C Human Atrial Natriuretic Peptide Molecular Variant and the Risk of Cardiovascular Diseases
por: Rubattu, Speranza, et al.
Publicado: (2018)

Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms
por: Stanzione, Rosita, et al.
Publicado: (2020)

The C2238/αANP Variant Is a Negative Modulator of Both Viability and Function of Coronary Artery Smooth Muscle Cells
por: Rubattu, Speranza, et al.
Publicado: (2014)

Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension
por: Gallo, Giovanna, et al.
Publicado: (2023)

An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation
por: Forte, Maurizio, et al.
Publicado: (2021)

Uncoupling Protein 2 as a Pathogenic Determinant and Therapeutic Target in Cardiovascular and Metabolic Diseases
por: Stanzione, Rosita, et al.
Publicado: (2022)

A Decrease of Brain MicroRNA-122 Level Is an Early Marker of Cerebrovascular Disease in the Stroke-Prone Spontaneously Hypertensive Rat
por: Stanzione, Rosita, et al.
Publicado: (2017)

Differential Expression of Sphingolipid Metabolizing Enzymes in Spontaneously Hypertensive Rats: A Possible Substrate for Susceptibility to Brain and Kidney Damage
por: Pepe, Giuseppe, et al.
Publicado: (2021)

Impact of a NDUFC2 Variant on the Occurrence of Acute Coronary Syndromes
por: Gallo, Giovanna, et al.
Publicado: (2022)

Natriuretic Peptides, Cognitive Impairment and Dementia: An Intriguing Pathogenic Link with Implications in Hypertension
por: Gallo, Giovanna, et al.
Publicado: (2020)

Molecular Implications of Natriuretic Peptides in the Protection from Hypertension and Target Organ Damage Development
por: Rubattu, Speranza, et al.
Publicado: (2019)

Beneficial Effects of Citrus Bergamia Polyphenolic Fraction on Saline Load-Induced Injury in Primary Cerebral Endothelial Cells from the Stroke-Prone Spontaneously Hypertensive Rat Model
por: Stanzione, Rosita, et al.
Publicado: (2023)

Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats
por: Busceti, Carla L., et al.
Publicado: (2020)

Role of Uncoupling Protein 2 Gene Polymorphisms on the Risk of Ischemic Stroke in a Sardinian Population
por: Stanzione, Rosita, et al.
Publicado: (2022)

Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat
por: Rubattu, Speranza, et al.
Publicado: (2017)

C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro
por: Stanzione, R, et al.
Publicado: (2015)

Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains
por: Rubattu, Speranza, et al.
Publicado: (2015)

Atrial Natriuretic Peptide Single Nucleotide Polymorphisms in Patients with Nonfamilial Structural Atrial Fibrillation
por: Francia, Pietro, et al.
Publicado: (2013)

Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease
por: Rubattu, Speranza, et al.
Publicado: (2016)

A Contemporary View of Natriuretic Peptides in the SARS-CoV-2 Era
por: Rubattu, Speranza, et al.
Publicado: (2021)

In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit
por: Raffa, Salvatore, et al.
Publicado: (2017)

Editorial: Natriuretic Peptides in Cardiovascular Pathophysiology
por: Volpe, Massimo, et al.
Publicado: (2022)

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease
por: Rubattu, Speranza, et al.
Publicado: (2016)

Natriuretic Peptides: It Is Time for Guided Therapeutic Strategies Based on Their Molecular Mechanisms
por: Gallo, Giovanna, et al.
Publicado: (2023)

Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases
por: Pierelli, Giorgia, et al.
Publicado: (2017)

Inhibition of miR‐155 Attenuates Detrimental Vascular Effects of Tobacco Cigarette Smoking
por: Frati, Giacomo, et al.
Publicado: (2020)

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway
por: Busceti, Carla L., et al.
Publicado: (2017)

C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP
por: Carnevale, Roberto, et al.
Publicado: (2017)

Natriuretic Peptides in the Cardiovascular System: Multifaceted Roles in Physiology, Pathology and Therapeutics
por: Rubattu, Speranza, et al.
Publicado: (2019)

Targeting Syntaxin 17 to Improve Mitophagy in Heart Failure
por: Forte, Maurizio, et al.
Publicado: (2023)

Discovering a new role for the atrial natriuretic peptide: A novel risk factor for cardiovascular diseases
por: RUBATTU, SPERANZA, et al.
Publicado: (2006)

Circulating Leukocytes and Oxidative Stress in Cardiovascular Diseases: A State of the Art
por: Rubattu, Speranza, et al.
Publicado: (2019)

New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart
por: Ikeda, Yoshiyuki, et al.
Publicado: (2014)

MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation
por: Schirone, Leonardo, et al.
Publicado: (2023)

Cardiovascular Pleiotropic Effects of Natriuretic Peptides
por: Forte, Maurizio, et al.
Publicado: (2019)

Resetting the neurohormonal balance in heart failure (HF): the relevance of the natriuretic peptide (NP) system to the clinical management of patients with HF
por: Rubattu, Speranza, et al.
Publicado: (2017)

Chronic heart failure is characterized by altered mitochondrial function and structure in circulating leucocytes
por: Coluccia, Roberta, et al.
Publicado: (2018)

Risk Stratification in Hypertrophic Cardiomyopathy. Insights from Genetic Analysis and Cardiopulmonary Exercise Testing
por: Magrì, Damiano, et al.
Publicado: (2020)

Sacubitril/Valsartan: Potential Impact of ARNi “Beyond the Wall” of ACE2 on Treatment and Prognosis of Heart Failure Patients With Coronavirus Disease-19
por: Rubattu, Speranza, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jgaki29qkuq095jvofls0ircq2