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Selective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling

BACKGROUND: Although trimodality therapy resecting tumours followed by chemoradiotherapy is emerged for muscle-invasive bladder cancer (MIBC), chemotherapy produces toxicities. Histone deacetylase inhibitors have been identified as an effective strategy to enhance cancer radiotherapy (RT). METHODS:...

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Detalles Bibliográficos
Autores principales: Tsai, Yu-Chieh, Wang, Tzu-Yin, Hsu, Chia-Lang, Lin, Wei-Chou, Chen, Jyun-Yu, Li, Jia-Hua, Pu, Yeong-Shiau, Cheng, Ann-Lii, Cheng, Jason Chia-Hsien, Su, Sheng-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133394/
https://www.ncbi.nlm.nih.gov/pubmed/36810912
http://dx.doi.org/10.1038/s41416-023-02195-0