Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids

Skin wound healing is a complex and multistage process, where any abnormalities at any stage can result in the accumulation of non-functional fibrotic tissue, leading to the formation of skin scars. Epigenetic modifications play a crucial role in regulating gene expression, inhibiting cell fate dete...

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Autores principales: Luo, Xiao, Zhu, Shu, Li, Jia, Zeng, Ning, Wang, Haiping, Wu, Yiping, Wang, Le, Liu, Zeming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133496/
https://www.ncbi.nlm.nih.gov/pubmed/37122849
http://dx.doi.org/10.3389/fbioe.2023.1143866
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author Luo, Xiao
Zhu, Shu
Li, Jia
Zeng, Ning
Wang, Haiping
Wu, Yiping
Wang, Le
Liu, Zeming
author_facet Luo, Xiao
Zhu, Shu
Li, Jia
Zeng, Ning
Wang, Haiping
Wu, Yiping
Wang, Le
Liu, Zeming
author_sort Luo, Xiao
collection PubMed
description Skin wound healing is a complex and multistage process, where any abnormalities at any stage can result in the accumulation of non-functional fibrotic tissue, leading to the formation of skin scars. Epigenetic modifications play a crucial role in regulating gene expression, inhibiting cell fate determination, and responding to environmental stimuli. m6A methylation is the most common post-transcriptional modification of eukaryotic mRNAs and long non-coding RNAs. However, it remains unclear how RNA methylation controls cell fate in different physiological environments. This review aims to discuss the current understanding of the regulatory pathways of RNA methylation in skin wound healing and their therapeutic implications with a focus on the specific mechanisms involved.
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spelling pubmed-101334962023-04-28 Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids Luo, Xiao Zhu, Shu Li, Jia Zeng, Ning Wang, Haiping Wu, Yiping Wang, Le Liu, Zeming Front Bioeng Biotechnol Bioengineering and Biotechnology Skin wound healing is a complex and multistage process, where any abnormalities at any stage can result in the accumulation of non-functional fibrotic tissue, leading to the formation of skin scars. Epigenetic modifications play a crucial role in regulating gene expression, inhibiting cell fate determination, and responding to environmental stimuli. m6A methylation is the most common post-transcriptional modification of eukaryotic mRNAs and long non-coding RNAs. However, it remains unclear how RNA methylation controls cell fate in different physiological environments. This review aims to discuss the current understanding of the regulatory pathways of RNA methylation in skin wound healing and their therapeutic implications with a focus on the specific mechanisms involved. Frontiers Media S.A. 2023-04-13 /pmc/articles/PMC10133496/ /pubmed/37122849 http://dx.doi.org/10.3389/fbioe.2023.1143866 Text en Copyright © 2023 Luo, Zhu, Li, Zeng, Wang, Wu, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Luo, Xiao
Zhu, Shu
Li, Jia
Zeng, Ning
Wang, Haiping
Wu, Yiping
Wang, Le
Liu, Zeming
Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids
title Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids
title_full Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids
title_fullStr Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids
title_full_unstemmed Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids
title_short Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids
title_sort potential genetic therapies based on m6a methylation for skin regeneration: wound healing and scars/keloids
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133496/
https://www.ncbi.nlm.nih.gov/pubmed/37122849
http://dx.doi.org/10.3389/fbioe.2023.1143866
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