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Advances in nanomaterial-based targeted drug delivery systems
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted deli...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133513/ https://www.ncbi.nlm.nih.gov/pubmed/37122851 http://dx.doi.org/10.3389/fbioe.2023.1177151 |
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author | Cheng, Xiaoxiao Xie, Qirong Sun, Yang |
author_facet | Cheng, Xiaoxiao Xie, Qirong Sun, Yang |
author_sort | Cheng, Xiaoxiao |
collection | PubMed |
description | Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted delivery systems were created to overcome the main drawbacks of conventional drug treatment, including insufficient stability and solubility, lack of transmembrane transport, short circulation time, and undesirable toxic effects. Herein, we reviewed the recent developments in different targeting design strategies and therapeutic approaches employing various nanomaterial-based systems. We also discussed the challenges and perspectives of smart systems in precisely targeting different intravascular and extravascular diseases. |
format | Online Article Text |
id | pubmed-10133513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101335132023-04-28 Advances in nanomaterial-based targeted drug delivery systems Cheng, Xiaoxiao Xie, Qirong Sun, Yang Front Bioeng Biotechnol Bioengineering and Biotechnology Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted delivery systems were created to overcome the main drawbacks of conventional drug treatment, including insufficient stability and solubility, lack of transmembrane transport, short circulation time, and undesirable toxic effects. Herein, we reviewed the recent developments in different targeting design strategies and therapeutic approaches employing various nanomaterial-based systems. We also discussed the challenges and perspectives of smart systems in precisely targeting different intravascular and extravascular diseases. Frontiers Media S.A. 2023-04-13 /pmc/articles/PMC10133513/ /pubmed/37122851 http://dx.doi.org/10.3389/fbioe.2023.1177151 Text en Copyright © 2023 Cheng, Xie and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Cheng, Xiaoxiao Xie, Qirong Sun, Yang Advances in nanomaterial-based targeted drug delivery systems |
title | Advances in nanomaterial-based targeted drug delivery systems |
title_full | Advances in nanomaterial-based targeted drug delivery systems |
title_fullStr | Advances in nanomaterial-based targeted drug delivery systems |
title_full_unstemmed | Advances in nanomaterial-based targeted drug delivery systems |
title_short | Advances in nanomaterial-based targeted drug delivery systems |
title_sort | advances in nanomaterial-based targeted drug delivery systems |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133513/ https://www.ncbi.nlm.nih.gov/pubmed/37122851 http://dx.doi.org/10.3389/fbioe.2023.1177151 |
work_keys_str_mv | AT chengxiaoxiao advancesinnanomaterialbasedtargeteddrugdeliverysystems AT xieqirong advancesinnanomaterialbasedtargeteddrugdeliverysystems AT sunyang advancesinnanomaterialbasedtargeteddrugdeliverysystems |