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Advances in nanomaterial-based targeted drug delivery systems

Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted deli...

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Detalles Bibliográficos
Autores principales: Cheng, Xiaoxiao, Xie, Qirong, Sun, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133513/
https://www.ncbi.nlm.nih.gov/pubmed/37122851
http://dx.doi.org/10.3389/fbioe.2023.1177151
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author Cheng, Xiaoxiao
Xie, Qirong
Sun, Yang
author_facet Cheng, Xiaoxiao
Xie, Qirong
Sun, Yang
author_sort Cheng, Xiaoxiao
collection PubMed
description Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted delivery systems were created to overcome the main drawbacks of conventional drug treatment, including insufficient stability and solubility, lack of transmembrane transport, short circulation time, and undesirable toxic effects. Herein, we reviewed the recent developments in different targeting design strategies and therapeutic approaches employing various nanomaterial-based systems. We also discussed the challenges and perspectives of smart systems in precisely targeting different intravascular and extravascular diseases.
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spelling pubmed-101335132023-04-28 Advances in nanomaterial-based targeted drug delivery systems Cheng, Xiaoxiao Xie, Qirong Sun, Yang Front Bioeng Biotechnol Bioengineering and Biotechnology Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted delivery systems were created to overcome the main drawbacks of conventional drug treatment, including insufficient stability and solubility, lack of transmembrane transport, short circulation time, and undesirable toxic effects. Herein, we reviewed the recent developments in different targeting design strategies and therapeutic approaches employing various nanomaterial-based systems. We also discussed the challenges and perspectives of smart systems in precisely targeting different intravascular and extravascular diseases. Frontiers Media S.A. 2023-04-13 /pmc/articles/PMC10133513/ /pubmed/37122851 http://dx.doi.org/10.3389/fbioe.2023.1177151 Text en Copyright © 2023 Cheng, Xie and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Cheng, Xiaoxiao
Xie, Qirong
Sun, Yang
Advances in nanomaterial-based targeted drug delivery systems
title Advances in nanomaterial-based targeted drug delivery systems
title_full Advances in nanomaterial-based targeted drug delivery systems
title_fullStr Advances in nanomaterial-based targeted drug delivery systems
title_full_unstemmed Advances in nanomaterial-based targeted drug delivery systems
title_short Advances in nanomaterial-based targeted drug delivery systems
title_sort advances in nanomaterial-based targeted drug delivery systems
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133513/
https://www.ncbi.nlm.nih.gov/pubmed/37122851
http://dx.doi.org/10.3389/fbioe.2023.1177151
work_keys_str_mv AT chengxiaoxiao advancesinnanomaterialbasedtargeteddrugdeliverysystems
AT xieqirong advancesinnanomaterialbasedtargeteddrugdeliverysystems
AT sunyang advancesinnanomaterialbasedtargeteddrugdeliverysystems