Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy

The development of efficient photosensitizers with high singlet oxygen quantum yield, strong fluorescent emission, excellent photostability, and specific organelle targeting is in great demand for the enhancement of PDT treatment efficiency. This study designed and synthesized a new two-photon photo...

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Detalles Bibliográficos
Autores principales: Xu, Le, Zhang, Tiantian, Huang, Bingcheng, Zheng, Fangmei, Huang, Yan, Li, Yuyang, Peng, Yiru, Chen, Linying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133558/
https://www.ncbi.nlm.nih.gov/pubmed/37124212
http://dx.doi.org/10.3389/fphar.2023.1168393
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author Xu, Le
Zhang, Tiantian
Huang, Bingcheng
Zheng, Fangmei
Huang, Yan
Li, Yuyang
Peng, Yiru
Chen, Linying
author_facet Xu, Le
Zhang, Tiantian
Huang, Bingcheng
Zheng, Fangmei
Huang, Yan
Li, Yuyang
Peng, Yiru
Chen, Linying
author_sort Xu, Le
collection PubMed
description The development of efficient photosensitizers with high singlet oxygen quantum yield, strong fluorescent emission, excellent photostability, and specific organelle targeting is in great demand for the enhancement of PDT treatment efficiency. This study designed and synthesized a new two-photon photosensitizer chlorophenyl thiophene axially substituted silicon (IV) phthalocyanine (CBT-SiPc). CBT-SiPc showed specific targeting of lysosomes in living cells and good biocompatibility. Furthermore, high (1)O(2) generation efficiency and high PDT efficiency in MCF-7 breast cancers under irradiation were also demonstrated. The novel CBT-SiPc showed great potential in the application of lysosome-targeted and two-photon bioimaging-guided photodynamic cancer therapy.
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spelling pubmed-101335582023-04-28 Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy Xu, Le Zhang, Tiantian Huang, Bingcheng Zheng, Fangmei Huang, Yan Li, Yuyang Peng, Yiru Chen, Linying Front Pharmacol Pharmacology The development of efficient photosensitizers with high singlet oxygen quantum yield, strong fluorescent emission, excellent photostability, and specific organelle targeting is in great demand for the enhancement of PDT treatment efficiency. This study designed and synthesized a new two-photon photosensitizer chlorophenyl thiophene axially substituted silicon (IV) phthalocyanine (CBT-SiPc). CBT-SiPc showed specific targeting of lysosomes in living cells and good biocompatibility. Furthermore, high (1)O(2) generation efficiency and high PDT efficiency in MCF-7 breast cancers under irradiation were also demonstrated. The novel CBT-SiPc showed great potential in the application of lysosome-targeted and two-photon bioimaging-guided photodynamic cancer therapy. Frontiers Media S.A. 2023-04-13 /pmc/articles/PMC10133558/ /pubmed/37124212 http://dx.doi.org/10.3389/fphar.2023.1168393 Text en Copyright © 2023 Xu, Zhang, Huang, Zheng, Huang, Li, Peng and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Xu, Le
Zhang, Tiantian
Huang, Bingcheng
Zheng, Fangmei
Huang, Yan
Li, Yuyang
Peng, Yiru
Chen, Linying
Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy
title Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy
title_full Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy
title_fullStr Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy
title_full_unstemmed Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy
title_short Chlorophenyl thiophene silicon phthalocyanine: Synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy
title_sort chlorophenyl thiophene silicon phthalocyanine: synthesis, two-photon bioimaging-guided lysosome target, and in vitro photodynamic efficacy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133558/
https://www.ncbi.nlm.nih.gov/pubmed/37124212
http://dx.doi.org/10.3389/fphar.2023.1168393
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