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Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis
The emergence of multi-drug resistance (MDR) in aquatic pathogens and the presence of cationic dyes are the leading causes of water contamination on a global scale. In this context, nanotechnology holds immense promise for utilizing various nanomaterials with catalytic and antibacterial properties....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133565/ https://www.ncbi.nlm.nih.gov/pubmed/37123878 http://dx.doi.org/10.3389/fchem.2023.1167701 |
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author | Ikram, Muhammad Shahzadi, Anum Bilal, Muhammad Haider, Ali Ul-Hamid, Anwar Nabgan, Walid Haider, Junaid Ali, Salamat Medina, Francisco Imran, Muhammad |
author_facet | Ikram, Muhammad Shahzadi, Anum Bilal, Muhammad Haider, Ali Ul-Hamid, Anwar Nabgan, Walid Haider, Junaid Ali, Salamat Medina, Francisco Imran, Muhammad |
author_sort | Ikram, Muhammad |
collection | PubMed |
description | The emergence of multi-drug resistance (MDR) in aquatic pathogens and the presence of cationic dyes are the leading causes of water contamination on a global scale. In this context, nanotechnology holds immense promise for utilizing various nanomaterials with catalytic and antibacterial properties. This study aimed to evaluate the catalytic and bactericidal potential of undoped and Sr-doped Cr(2)O(3) nanostructures (NSs) synthesized through the co-precipitation method. In addition, the morphological, optical, and structural properties of the resultant NSs were also examined. The optical bandgap energy of Cr(2)O(3) has been substantially reduced by Sr doping, as confirmed through extracted values from absorption spectra recorded by UV-Vis studies. The field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) micrographs illustrate that the composition of Cr(2)O(3) primarily consisted of agglomerated, irregularly shaped NSs with a morphology resembling nanoflakes. Moreover, the presence of Sr in the lattice of Cr(2)O(3) increased the roughness of the resulting NSs. The catalytic activity of synthesized NSs was analyzed by their reduction ability of Rhodamine B (RhB) dye in the dark under different pH conditions. Their antibacterial activity was evaluated against MDR Escherichia coli (E. coli). Sr doping increased antibacterial efficiency against MDR E. coli, as indicated by inhibition zone measurements of 10.15 and 11.75 mm at low and high doses, respectively. Furthermore, a molecular docking analysis was conducted to determine the binding interaction pattern between NSs and active sites in the target cell protein. The findings corroborated antimicrobial test results indicating that Sr-Cr(2)O(3) is the most effective inhibitor of FabH and DHFR enzymes. |
format | Online Article Text |
id | pubmed-10133565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101335652023-04-28 Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis Ikram, Muhammad Shahzadi, Anum Bilal, Muhammad Haider, Ali Ul-Hamid, Anwar Nabgan, Walid Haider, Junaid Ali, Salamat Medina, Francisco Imran, Muhammad Front Chem Chemistry The emergence of multi-drug resistance (MDR) in aquatic pathogens and the presence of cationic dyes are the leading causes of water contamination on a global scale. In this context, nanotechnology holds immense promise for utilizing various nanomaterials with catalytic and antibacterial properties. This study aimed to evaluate the catalytic and bactericidal potential of undoped and Sr-doped Cr(2)O(3) nanostructures (NSs) synthesized through the co-precipitation method. In addition, the morphological, optical, and structural properties of the resultant NSs were also examined. The optical bandgap energy of Cr(2)O(3) has been substantially reduced by Sr doping, as confirmed through extracted values from absorption spectra recorded by UV-Vis studies. The field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) micrographs illustrate that the composition of Cr(2)O(3) primarily consisted of agglomerated, irregularly shaped NSs with a morphology resembling nanoflakes. Moreover, the presence of Sr in the lattice of Cr(2)O(3) increased the roughness of the resulting NSs. The catalytic activity of synthesized NSs was analyzed by their reduction ability of Rhodamine B (RhB) dye in the dark under different pH conditions. Their antibacterial activity was evaluated against MDR Escherichia coli (E. coli). Sr doping increased antibacterial efficiency against MDR E. coli, as indicated by inhibition zone measurements of 10.15 and 11.75 mm at low and high doses, respectively. Furthermore, a molecular docking analysis was conducted to determine the binding interaction pattern between NSs and active sites in the target cell protein. The findings corroborated antimicrobial test results indicating that Sr-Cr(2)O(3) is the most effective inhibitor of FabH and DHFR enzymes. Frontiers Media S.A. 2023-04-13 /pmc/articles/PMC10133565/ /pubmed/37123878 http://dx.doi.org/10.3389/fchem.2023.1167701 Text en Copyright © 2023 Ikram, Shahzadi, Bilal, Haider, Ul-Hamid, Nabgan, Haider, Ali, Medina and Imran. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Ikram, Muhammad Shahzadi, Anum Bilal, Muhammad Haider, Ali Ul-Hamid, Anwar Nabgan, Walid Haider, Junaid Ali, Salamat Medina, Francisco Imran, Muhammad Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis |
title | Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis |
title_full | Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis |
title_fullStr | Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis |
title_full_unstemmed | Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis |
title_short | Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis |
title_sort | strontium-doped chromium oxide for rhb reduction and antibacterial activity with evidence of molecular docking analysis |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133565/ https://www.ncbi.nlm.nih.gov/pubmed/37123878 http://dx.doi.org/10.3389/fchem.2023.1167701 |
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