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Factors associated with poor outcomes in patients with severe acute respiratory infections in Bahrain

BACKGROUND: Severe acute respiratory tract infection (SARI) is a major global health threat. This study aimed to examine risk factors associated with poor outcomes in patients with SARI. METHODS: All patients who met World Health Organization's (WHO) SARI case definition and were admitted to Sa...

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Autores principales: Mohamed, Afaf Merza, Al Sayyad, Adel, Matar, Ebrahim, Isa, Hasan M., Hasan, Wafa Fawzi, Hashim, Nawra Sayed Jalal Yusuf, Alajaimi, Bayan Abduljalil, Aldolabi, Qatrmeer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133729/
https://www.ncbi.nlm.nih.gov/pubmed/37123813
http://dx.doi.org/10.1111/irv.13133
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author Mohamed, Afaf Merza
Al Sayyad, Adel
Matar, Ebrahim
Isa, Hasan M.
Hasan, Wafa Fawzi
Hashim, Nawra Sayed Jalal Yusuf
Alajaimi, Bayan Abduljalil
Aldolabi, Qatrmeer
author_facet Mohamed, Afaf Merza
Al Sayyad, Adel
Matar, Ebrahim
Isa, Hasan M.
Hasan, Wafa Fawzi
Hashim, Nawra Sayed Jalal Yusuf
Alajaimi, Bayan Abduljalil
Aldolabi, Qatrmeer
author_sort Mohamed, Afaf Merza
collection PubMed
description BACKGROUND: Severe acute respiratory tract infection (SARI) is a major global health threat. This study aimed to examine risk factors associated with poor outcomes in patients with SARI. METHODS: All patients who met World Health Organization's (WHO) SARI case definition and were admitted to Salmaniya Medical Complex from January 2018 to December 2021 were included. Epidemiological and virological data were obtained and analyzed. RESULTS: Of 1159 patients with SARI included, 731 (63.1%) patients were below 50 years, and 357 (30.8%) tested positive for viral pathogens. The most prevalent virus was Flu‐A (n = 134, 37.5%), SARS‐CoV2 (n = 118, 33%), RSV (n = 51, 14.3%), Flu B (n = 49,13.7%), other viruses (n = 3, 0.8%), and combined infection (n = 2, 0.6%). Six hundred fifty‐eight (56.8%) patients had comorbidities, mainly diabetes (n = 284, 43%) and heart disease ( n  = 217, 33%). 183 (16%) patients were admitted to ICU, 110 (9%) needed mechanical ventilation, and 80 (7%) patients died. The odds of ICU admission were higher for patients with hematological (OR 5.9, 95% CI 3.1–11.1) and lung diseases (OR 2.7, 95% CI 1.6–4.6). The odds of mechanical ventilation were higher among patients with lung disease (OR 3.1, 95% 1.7–5.5). The mortality odds were higher among patients above 50 (OR 2.4, 95% CI 1.4–4.1) and chronic kidney disease (OR 2.5, 95% CI 1.1–5.2). CONCLUSIONS: Being 50 years or above or having kidney, lung, or heart diseases was associated with worse SARI outcomes. Efforts and actions in developing better strategies to vaccinate individuals at high risk and early diagnosis and treatment should help in reducing the burden of SARI.
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spelling pubmed-101337292023-04-28 Factors associated with poor outcomes in patients with severe acute respiratory infections in Bahrain Mohamed, Afaf Merza Al Sayyad, Adel Matar, Ebrahim Isa, Hasan M. Hasan, Wafa Fawzi Hashim, Nawra Sayed Jalal Yusuf Alajaimi, Bayan Abduljalil Aldolabi, Qatrmeer Influenza Other Respir Viruses Original Articles BACKGROUND: Severe acute respiratory tract infection (SARI) is a major global health threat. This study aimed to examine risk factors associated with poor outcomes in patients with SARI. METHODS: All patients who met World Health Organization's (WHO) SARI case definition and were admitted to Salmaniya Medical Complex from January 2018 to December 2021 were included. Epidemiological and virological data were obtained and analyzed. RESULTS: Of 1159 patients with SARI included, 731 (63.1%) patients were below 50 years, and 357 (30.8%) tested positive for viral pathogens. The most prevalent virus was Flu‐A (n = 134, 37.5%), SARS‐CoV2 (n = 118, 33%), RSV (n = 51, 14.3%), Flu B (n = 49,13.7%), other viruses (n = 3, 0.8%), and combined infection (n = 2, 0.6%). Six hundred fifty‐eight (56.8%) patients had comorbidities, mainly diabetes (n = 284, 43%) and heart disease ( n  = 217, 33%). 183 (16%) patients were admitted to ICU, 110 (9%) needed mechanical ventilation, and 80 (7%) patients died. The odds of ICU admission were higher for patients with hematological (OR 5.9, 95% CI 3.1–11.1) and lung diseases (OR 2.7, 95% CI 1.6–4.6). The odds of mechanical ventilation were higher among patients with lung disease (OR 3.1, 95% 1.7–5.5). The mortality odds were higher among patients above 50 (OR 2.4, 95% CI 1.4–4.1) and chronic kidney disease (OR 2.5, 95% CI 1.1–5.2). CONCLUSIONS: Being 50 years or above or having kidney, lung, or heart diseases was associated with worse SARI outcomes. Efforts and actions in developing better strategies to vaccinate individuals at high risk and early diagnosis and treatment should help in reducing the burden of SARI. John Wiley and Sons Inc. 2023-04-26 /pmc/articles/PMC10133729/ /pubmed/37123813 http://dx.doi.org/10.1111/irv.13133 Text en © 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Mohamed, Afaf Merza
Al Sayyad, Adel
Matar, Ebrahim
Isa, Hasan M.
Hasan, Wafa Fawzi
Hashim, Nawra Sayed Jalal Yusuf
Alajaimi, Bayan Abduljalil
Aldolabi, Qatrmeer
Factors associated with poor outcomes in patients with severe acute respiratory infections in Bahrain
title Factors associated with poor outcomes in patients with severe acute respiratory infections in Bahrain
title_full Factors associated with poor outcomes in patients with severe acute respiratory infections in Bahrain
title_fullStr Factors associated with poor outcomes in patients with severe acute respiratory infections in Bahrain
title_full_unstemmed Factors associated with poor outcomes in patients with severe acute respiratory infections in Bahrain
title_short Factors associated with poor outcomes in patients with severe acute respiratory infections in Bahrain
title_sort factors associated with poor outcomes in patients with severe acute respiratory infections in bahrain
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133729/
https://www.ncbi.nlm.nih.gov/pubmed/37123813
http://dx.doi.org/10.1111/irv.13133
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