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The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah

Background Graves’ disease (GD) is an autoimmune disease, with thyrotropin receptor antibodies (TRAbs) being the most important cause in the pathogenesis. The aim of this study is to assess the clinical significance of anti-TPO Abs in GD. Methods A retrospective study was conducted at the Faiha spec...

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Autores principales: Alhubaish, Emad S, Alibrahim, Nassar T, Mansour, Abbas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133893/
https://www.ncbi.nlm.nih.gov/pubmed/37123800
http://dx.doi.org/10.7759/cureus.36778
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author Alhubaish, Emad S
Alibrahim, Nassar T
Mansour, Abbas A
author_facet Alhubaish, Emad S
Alibrahim, Nassar T
Mansour, Abbas A
author_sort Alhubaish, Emad S
collection PubMed
description Background Graves’ disease (GD) is an autoimmune disease, with thyrotropin receptor antibodies (TRAbs) being the most important cause in the pathogenesis. The aim of this study is to assess the clinical significance of anti-TPO Abs in GD. Methods A retrospective study was conducted at the Faiha specialized Diabetes, Endocrine, and Metabolism Center (FDEMC) in Basrah during the period between December 2021 and December 2022. A total of 141 patients with GD were involved in this study, and of them, 97 (68.8%) were women. They were divided into two groups: patients with positive and negative anti-TPO Abs groups. Results Positive anti-TPO Abs were seen in 83 patients (58.9%) with GD. Pretreatment-free thyroxine level (ng/dL) was higher in the anti-TPO Abs positive GD patients than in those with negative antibodies (3.7±0.2 versus 3.0±0.2 with a p=0.021). Similarly, higher TRAb titers (IU/ml) at baseline were also seen in patients with positive anti-TPO Abs (9.8±0.7 versus 6.8±0.8) with a p=0.008. Giraffe appearance on thyroid ultrasound was more common in the group with positive anti-TPO Abs as compared to patients with negative anti-TPO Abs: 20 (87.0%) versus 3 (13.0%) with a p=0.005. A higher anti-TPO Abs titer (IU/mL) was associated with a baseline TRAb level of more than 6.4 IU/mL, and giraffe appearance on thyroid ultrasound (206.5±20.0 p-value<0.0001 and 228.0±35.3 p value=0.007, respectively). Conclusion A positive anti-TPO Abs in GD is associated with a high TRAb titer and free T4 level at baseline, as well as a giraffe appearance on thyroid ultrasound.
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spelling pubmed-101338932023-04-28 The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah Alhubaish, Emad S Alibrahim, Nassar T Mansour, Abbas A Cureus Endocrinology/Diabetes/Metabolism Background Graves’ disease (GD) is an autoimmune disease, with thyrotropin receptor antibodies (TRAbs) being the most important cause in the pathogenesis. The aim of this study is to assess the clinical significance of anti-TPO Abs in GD. Methods A retrospective study was conducted at the Faiha specialized Diabetes, Endocrine, and Metabolism Center (FDEMC) in Basrah during the period between December 2021 and December 2022. A total of 141 patients with GD were involved in this study, and of them, 97 (68.8%) were women. They were divided into two groups: patients with positive and negative anti-TPO Abs groups. Results Positive anti-TPO Abs were seen in 83 patients (58.9%) with GD. Pretreatment-free thyroxine level (ng/dL) was higher in the anti-TPO Abs positive GD patients than in those with negative antibodies (3.7±0.2 versus 3.0±0.2 with a p=0.021). Similarly, higher TRAb titers (IU/ml) at baseline were also seen in patients with positive anti-TPO Abs (9.8±0.7 versus 6.8±0.8) with a p=0.008. Giraffe appearance on thyroid ultrasound was more common in the group with positive anti-TPO Abs as compared to patients with negative anti-TPO Abs: 20 (87.0%) versus 3 (13.0%) with a p=0.005. A higher anti-TPO Abs titer (IU/mL) was associated with a baseline TRAb level of more than 6.4 IU/mL, and giraffe appearance on thyroid ultrasound (206.5±20.0 p-value<0.0001 and 228.0±35.3 p value=0.007, respectively). Conclusion A positive anti-TPO Abs in GD is associated with a high TRAb titer and free T4 level at baseline, as well as a giraffe appearance on thyroid ultrasound. Cureus 2023-03-28 /pmc/articles/PMC10133893/ /pubmed/37123800 http://dx.doi.org/10.7759/cureus.36778 Text en Copyright © 2023, Alhubaish et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Alhubaish, Emad S
Alibrahim, Nassar T
Mansour, Abbas A
The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah
title The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah
title_full The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah
title_fullStr The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah
title_full_unstemmed The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah
title_short The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah
title_sort clinical implications of anti-thyroid peroxidase antibodies in graves’ disease in basrah
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133893/
https://www.ncbi.nlm.nih.gov/pubmed/37123800
http://dx.doi.org/10.7759/cureus.36778
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