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An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review

Introduction: Follicular dendritic cell sarcomas (FDCS) are rare tumours, typically seen in lymph nodes. However, in about one third of the reported cases, a FDCS presents as an extranodal mass. Involvement of the gastrointestinal tract is rare, and the stomach is even rarer with only four cases des...

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Autores principales: Sassi, Farah, Sahraoui, Ghada, Charfi, Lamia, Achouri, Leila, Doghri, Raoudha, Mrad, Karima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134144/
https://www.ncbi.nlm.nih.gov/pubmed/37124840
http://dx.doi.org/10.1177/20363613231172077
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author Sassi, Farah
Sahraoui, Ghada
Charfi, Lamia
Achouri, Leila
Doghri, Raoudha
Mrad, Karima
author_facet Sassi, Farah
Sahraoui, Ghada
Charfi, Lamia
Achouri, Leila
Doghri, Raoudha
Mrad, Karima
author_sort Sassi, Farah
collection PubMed
description Introduction: Follicular dendritic cell sarcomas (FDCS) are rare tumours, typically seen in lymph nodes. However, in about one third of the reported cases, a FDCS presents as an extranodal mass. Involvement of the gastrointestinal tract is rare, and the stomach is even rarer with only four cases described to date. The aim of this study was to review clinical characteristics, pathologic features, emphasize on differential diagnosis and discuss therapeutic modalities and prognosis of this rare entity.Case presentation: We report on a 36-year-old female patient with no past medical history, an incidentally discovered FDCS located in the stomach with the presence of lymph node metastasis at the time of diagnosis. The diagnosis of a FDCS was made on morphological and immunohistochemical findings where tumor cells expressed CD21 and CD23. The tumor was resected by gastrectomy with extended para-aortic lymphadenectomy, with uneventful postoperative course.Conclusions: Due to its rarity, FDCS is rarely included in the differential diagnosis of gastrointestinal spindle cell tumors. Complete surgical resection is the current gold standard of treatment.
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spelling pubmed-101341442023-04-28 An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review Sassi, Farah Sahraoui, Ghada Charfi, Lamia Achouri, Leila Doghri, Raoudha Mrad, Karima Rare Tumors Case Report Introduction: Follicular dendritic cell sarcomas (FDCS) are rare tumours, typically seen in lymph nodes. However, in about one third of the reported cases, a FDCS presents as an extranodal mass. Involvement of the gastrointestinal tract is rare, and the stomach is even rarer with only four cases described to date. The aim of this study was to review clinical characteristics, pathologic features, emphasize on differential diagnosis and discuss therapeutic modalities and prognosis of this rare entity.Case presentation: We report on a 36-year-old female patient with no past medical history, an incidentally discovered FDCS located in the stomach with the presence of lymph node metastasis at the time of diagnosis. The diagnosis of a FDCS was made on morphological and immunohistochemical findings where tumor cells expressed CD21 and CD23. The tumor was resected by gastrectomy with extended para-aortic lymphadenectomy, with uneventful postoperative course.Conclusions: Due to its rarity, FDCS is rarely included in the differential diagnosis of gastrointestinal spindle cell tumors. Complete surgical resection is the current gold standard of treatment. SAGE Publications 2023-04-26 /pmc/articles/PMC10134144/ /pubmed/37124840 http://dx.doi.org/10.1177/20363613231172077 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Sassi, Farah
Sahraoui, Ghada
Charfi, Lamia
Achouri, Leila
Doghri, Raoudha
Mrad, Karima
An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review
title An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review
title_full An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review
title_fullStr An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review
title_full_unstemmed An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review
title_short An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review
title_sort incidental discovery of a gastric follicular dendritic cell sarcoma: a rare case report and a literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134144/
https://www.ncbi.nlm.nih.gov/pubmed/37124840
http://dx.doi.org/10.1177/20363613231172077
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