Cargando…

Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins

Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In the process of virus replication, amino acid substitutions con...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Li, Chen, Hualan, Li, Chengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134199/
https://www.ncbi.nlm.nih.gov/pubmed/37193064
http://dx.doi.org/10.1016/j.cellin.2023.100079
_version_ 1785031708548005888
author Jiang, Li
Chen, Hualan
Li, Chengjun
author_facet Jiang, Li
Chen, Hualan
Li, Chengjun
author_sort Jiang, Li
collection PubMed
description Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In the process of virus replication, amino acid substitutions continuously accumulate, and genetic reassortment between virus strains readily occurs. Due to this high genetic variability, new viruses that threaten animal and human health can emerge at any time. Therefore, the study on IAV has always been a focus of veterinary medicine and public health. The replication, pathogenesis, and transmission of IAV involve intricate interplay between the virus and host. On one hand, the entire replication cycle of IAV relies on numerous proviral host proteins that effectively allow the virus to adapt to its host and support its replication. On the other hand, some host proteins play restricting roles at different stages of the viral replication cycle. The mechanisms of interaction between viral proteins and host cellular proteins are currently receiving particular interest in IAV research. In this review, we briefly summarize the current advances in our understanding of the mechanisms by which host proteins affect virus replication, pathogenesis, or transmission by interacting with viral proteins. Such information about the interplay between IAV and host proteins could provide insights into how IAV causes disease and spreads, and might help support the development of antiviral drugs or therapeutic approaches.
format Online
Article
Text
id pubmed-10134199
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-101341992023-05-15 Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins Jiang, Li Chen, Hualan Li, Chengjun Cell Insight Review Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In the process of virus replication, amino acid substitutions continuously accumulate, and genetic reassortment between virus strains readily occurs. Due to this high genetic variability, new viruses that threaten animal and human health can emerge at any time. Therefore, the study on IAV has always been a focus of veterinary medicine and public health. The replication, pathogenesis, and transmission of IAV involve intricate interplay between the virus and host. On one hand, the entire replication cycle of IAV relies on numerous proviral host proteins that effectively allow the virus to adapt to its host and support its replication. On the other hand, some host proteins play restricting roles at different stages of the viral replication cycle. The mechanisms of interaction between viral proteins and host cellular proteins are currently receiving particular interest in IAV research. In this review, we briefly summarize the current advances in our understanding of the mechanisms by which host proteins affect virus replication, pathogenesis, or transmission by interacting with viral proteins. Such information about the interplay between IAV and host proteins could provide insights into how IAV causes disease and spreads, and might help support the development of antiviral drugs or therapeutic approaches. Elsevier 2023-01-31 /pmc/articles/PMC10134199/ /pubmed/37193064 http://dx.doi.org/10.1016/j.cellin.2023.100079 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jiang, Li
Chen, Hualan
Li, Chengjun
Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins
title Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins
title_full Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins
title_fullStr Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins
title_full_unstemmed Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins
title_short Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins
title_sort advances in deciphering the interactions between viral proteins of influenza a virus and host cellular proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134199/
https://www.ncbi.nlm.nih.gov/pubmed/37193064
http://dx.doi.org/10.1016/j.cellin.2023.100079
work_keys_str_mv AT jiangli advancesindecipheringtheinteractionsbetweenviralproteinsofinfluenzaavirusandhostcellularproteins
AT chenhualan advancesindecipheringtheinteractionsbetweenviralproteinsofinfluenzaavirusandhostcellularproteins
AT lichengjun advancesindecipheringtheinteractionsbetweenviralproteinsofinfluenzaavirusandhostcellularproteins