Binding Analysis and Structure-Based Design of Tricyclic Coumarin-Derived MTHFD2 Inhibitors as Anticancer Agents: Insights from Computational Modeling

[Image: see text] Unfolded protein response (UPR)-dependent metabolic reprogramming diverts metabolites from glycolysis to mitochondrial 1C metabolism, highlighting pharmacological resistance to folate drugs and overexpression of certain enzymes. Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a...

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Detalles Bibliográficos
Autores principales: Jha, Vibhu, Holmelin, Fredrik Lannestam, Eriksson, Leif A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134251/
https://www.ncbi.nlm.nih.gov/pubmed/37125100
http://dx.doi.org/10.1021/acsomega.2c08025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134251/
https://www.ncbi.nlm.nih.gov/pubmed/37125100
http://dx.doi.org/10.1021/acsomega.2c08025

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