Molecularly Engineered Surfactin Analogues Induce Nonapoptotic-Like Cell Death and Increased Selectivity in Multiple Breast Cancer Cell Types

[Image: see text] Surfactin, a negatively charged amphiphilic lipopeptide biosurfactant, is synthesized by the bacterium Bacillus subtilis. It consists of a cyclic heptapeptide and an 11–15C β-hydroxy fatty acid. To probe how the modification of the molecular skeleton of surfactin influences its sel...

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Detalles Bibliográficos
Autores principales: Miceli, Rebecca T., Totsingan, Filbert, Naina, Tasnim, Islam, Samita, Dordick, Jonathan S., Corr, David T., Gross, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134466/
https://www.ncbi.nlm.nih.gov/pubmed/37125141
http://dx.doi.org/10.1021/acsomega.3c00454

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