Cargando…

Prominent epigenetic and transcriptomic changes in CD4(+) and CD8(+) T cells during and after pregnancy in women with multiple sclerosis and controls

BACKGROUND: Multiple sclerosis (MS) is a neuroinflammatory disease in which pregnancy leads to a temporary amelioration in disease activity as indicated by the profound decrease in relapses rate during the 3rd trimester of pregnancy. CD4(+) and CD8(+) T cells are implicated in MS pathogenesis as bei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zenere, Alberto, Hellberg, Sandra, Papapavlou Lingehed, Georgia, Svenvik, Maria, Mellergård, Johan, Dahle, Charlotte, Vrethem, Magnus, Raffetseder, Johanna, Khademi, Mohsen, Olsson, Tomas, Blomberg, Marie, Jenmalm, Maria C., Altafini, Claudio, Gustafsson, Mika, Ernerudh, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134602/ https://www.ncbi.nlm.nih.gov/pubmed/37106402 http://dx.doi.org/10.1186/s12974-023-02781-2

Ejemplares similares

Plasma protein profiling reveals dynamic immunomodulatory changes in multiple sclerosis patients during pregnancy
por: Papapavlou Lingehed, Georgia, et al.
Publicado: (2022)

Progesterone Dampens Immune Responses in In Vitro Activated CD4(+) T Cells and Affects Genes Associated With Autoimmune Diseases That Improve During Pregnancy
por: Hellberg, Sandra, et al.
Publicado: (2021)

Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis
por: Åkesson, Julia, et al.
Publicado: (2023)

Increased B Cell and Cytotoxic NK Cell Proportions and Increased T Cell Responsiveness in Blood of Natalizumab-Treated Multiple Sclerosis Patients
por: Mellergård, Johan, et al.
Publicado: (2013)

Preterm Birth: A Prominent Risk Factor for Low Apgar Scores
por: Svenvik, Maria, et al.
Publicado: (2015)

Association between Change in Normal Appearing White Matter Metabolites and Intrathecal Inflammation in Natalizumab-Treated Multiple Sclerosis
por: Mellergård, Johan, et al.
Publicado: (2012)

T-lymphocyte subset abnormalities in the Guillain-Barré syndrome
por: Dahle, C., et al.
Publicado: (1994)

RNA-sequencing and mass-spectrometry proteomic time-series analysis of T-cell differentiation identified multiple splice variants models that predicted validated protein biomarkers in inflammatory diseases
por: Magnusson, Rasmus, et al.
Publicado: (2022)

Multi-omics protein-coding units as massively parallel Bayesian networks: Empirical validation of causality structure
por: Zenere, Alberto, et al.
Publicado: (2022)

Using high-throughput multi-omics data to investigate structural balance in elementary gene regulatory network motifs
por: Zenere, Alberto, et al.
Publicado: (2021)

CD4(+) T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases
por: Badam, Tejaswi V., et al.
Publicado: (2021)

Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells
por: Huoman, Johanna, et al.
Publicado: (2021)

Progesterone Inhibits the Establishment of Activation-Associated Chromatin During T(H)1 Differentiation
por: Rundquist, Olof, et al.
Publicado: (2022)

Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis
por: Håkansson, Irene, et al.
Publicado: (2018)

Subacute neuronopathy in a young man: a possible association with tetracycline treatment
por: Vrethem, Magnus, et al.
Publicado: (2011)

Adaptive and Innate Immune Responsiveness to Borrelia burgdorferi sensu lato in Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis
por: Skogman, Barbro H., et al.
Publicado: (2012)

Clinical, diagnostic and immunological characteristics of patients with possible neuroborreliosis without intrathecal Ig-synthesis against Borrelia antigen in the cerebrospinal fluid
por: Vrethem, Magnus, et al.
Publicado: (2011)

Increased Numbers of IL-7 Receptor Molecules on CD4+CD25−CD107a+ T-Cells in Patients with Autoimmune Diseases Affecting the Central Nervous System
por: Vudattu, Nalini Kumar, et al.
Publicado: (2009)

Increased prevalence of celiac disease in idiopathic inflammatory myopathies
por: Danielsson, Olof, et al.
Publicado: (2017)

Maternal childbirth experience and time in labor: a population-based cohort study
por: Carlhäll, Sara, et al.
Publicado: (2022)

MAIT Cells at the Fetal-Maternal Interface During Pregnancy
por: Kaipe, Helen, et al.
Publicado: (2020)

Thermodynamic model of gene regulation for the Or59b olfactory receptor in Drosophila
por: González, Alejandra, et al.
Publicado: (2019)

Improved working ability in a contemporary MS population compared with a historic non-treated MS population in the same geographic area of Sweden
por: Wickström, Anne, et al.
Publicado: (2015)

Insights into SusCD-mediated glycan import by a prominent gut symbiont
por: Gray, Declan A., et al.
Publicado: (2021)

Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4(+ )T cells in sarcoidosis
por: Idali, Farah, et al.
Publicado: (2009)

MAIT Cells Balance the Requirements for Immune Tolerance and Anti-Microbial Defense During Pregnancy
por: Raffetseder, Johanna, et al.
Publicado: (2021)

The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study
por: Strindhall, J., et al.
Publicado: (2012)

Effects of low molecular weight heparin on the polarization and cytokine profile of macrophages and T helper cells in vitro
por: Bruno, Valentina, et al.
Publicado: (2018)

EURISOL Design Study CD Report
por: Facco, A, et al.
Publicado: (08/0)

Intralymphatic immunotherapy with one or two allergens renders similar clinical response in patients with allergic rhinitis due to birch and grass pollen
por: Ahlbeck, Lars, et al.
Publicado: (2022)

Parathyroid Adenoma with Prominent Lymphocytic Infiltrate
por: Iliadis, Alexandros, et al.
Publicado: (2015)

Transcriptional signatures of Itk-deficient CD3(+), CD4(+ )and CD8(+ )T-cells
por: Blomberg, K Emelie M, et al.
Publicado: (2009)

Changes in peripheral immune populations during pregnancy and modulation by probiotics and ω-3 fatty acids
por: Forsberg, A., et al.
Publicado: (2020)

The prominent role of the S100A8/S100A9-CD147 axis in the progression of penile cancer
por: Mohr, Tobias, et al.
Publicado: (2022)

Apoptosis in idiopathic inflammatory myopathies with partial invasion; a role for CD8(+) cytotoxic T cells?
por: Danielsson, Olof, et al.
Publicado: (2020)

Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8(+) T-cell response, prominent infiltration of CD8(+) lymphocytes and Th1 type polarization
por: Ranki, Tuuli, et al.
Publicado: (2014)

Labour promotes systemic mobilisation of monocytes, T cell activation and local secretion of chemotactic factors in the intervillous space of the placenta
por: Vikberg, Sara, et al.
Publicado: (2023)

The follow-up of patients of sixty-five years of age and younger with acute ischemic stroke and transient ischemic attacks, and elevated D-dimer levels in plasma
por: Vrethem, Magnus, et al.
Publicado: (2009)

Iba-1(-)/CD68(+) microglia are a prominent feature of age-associated deep subcortical white matter lesions
por: Waller, Rachel, et al.
Publicado: (2019)

A rare case of dual expression of CD5 and CD10 in primary central nervous system diffuse large B‐cell lymphoma with prominent starry sky appearance
por: McCorkle, Colin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_io7pg3tmnsls1hs5g0um6cn1hk