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Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart

BACKGROUND: Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberrant activation of signaling pathways in a diabetic heart. Epigenetic marks play v...

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Detalles Bibliográficos
Autores principales:	Dhat, Rohini, Mongad, Dattatray, Raji, Sivarupa, Arkat, Silpa, Mahapatra, Nitish R., Singhal, Nishant, Sitasawad, Sandhya L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134649/ https://www.ncbi.nlm.nih.gov/pubmed/37101286 http://dx.doi.org/10.1186/s13072-023-00489-4

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