Impact of SARS-CoV2 infection on mortality and hospitalization in nursing home residents during the “Omicron era”

BACKGROUND: Widespread vaccination and emergence of less aggressive SARS-CoV2 variants may have blunted the unfavourable outcomes of COVID-19 in nursing home (NH) residents. We analysed the course of COVID-19 epidemic in NHs of Florence, Italy, during the “Omicron era” and investigated the independe...

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Detalles Bibliográficos
Autores principales: Bulgaresi, Matteo, Rivasi, Giulia, Tarantini, Francesca, Espinoza Tofalos, Sofia, Del Re, Lorenzo Maria, Salucci, Caterina, Turrin, Giada, Barucci, Riccardo, Bandinelli, Chiara, Fattorini, Letizia, Borchi, Daniele, Betti, Marta, Checchi, Saverio, Baggiani, Lorenzo, Collini, Francesca, Lorini, Chiara, Bonaccorsi, Guglielmo, Ungar, Andrea, Mossello, Enrico, Benvenuti, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134704/
https://www.ncbi.nlm.nih.gov/pubmed/37103663
http://dx.doi.org/10.1007/s40520-023-02415-w
Descripción
Sumario:BACKGROUND: Widespread vaccination and emergence of less aggressive SARS-CoV2 variants may have blunted the unfavourable outcomes of COVID-19 in nursing home (NH) residents. We analysed the course of COVID-19 epidemic in NHs of Florence, Italy, during the “Omicron era” and investigated the independent effect of SARS-CoV2 infection on death and hospitalization risk. METHODS: Weekly SARS-CoV2 infection rates between November 2021 and March 2022 were calculated. Detailed clinical data were collected in a sample of NHs. RESULTS: Among 2044 residents, 667 SARS-CoV2 cases were confirmed. SARS-CoV2 incidence sharply increased during the Omicron era. Mortality rates did not differ between SARS-CoV2-positive (6.9%) and SARS-CoV2-negative residents (7.3%, p = 0.71). Chronic obstructive pulmonary disease and poor functional status, but not SARS-CoV2 infection independently predicted death and hospitalization. CONCLUSIONS: Despite that SARS-CoV2 incidence increased during the Omicron era, SARS-CoV2 infection was not a significant predictor of hospitalization and death in the NH setting. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-023-02415-w.

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